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Research Article

Non-invasive Predictors of Human Cortical Bone Mechanical Properties: T2-Discriminated 1H NMR Compared with High Resolution X-ray

  • R. Adam Horch,

    Affiliations: Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, United States of America, Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Daniel F. Gochberg,

    Affiliations: Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States of America, Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Jeffry S. Nyman mail,

    jeffry.s.nyman@vanderbilt.edu (JSN); mark.does@vanderbilt.edu (MDD)

    Affiliations: Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, United States of America, VA Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America, Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Mark D. Does mail

    jeffry.s.nyman@vanderbilt.edu (JSN); mark.does@vanderbilt.edu (MDD)

    Affiliations: Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, United States of America, Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States of America, Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America, Department of Electrical Engineering, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Published: January 21, 2011
  • DOI: 10.1371/journal.pone.0016359

About the Authors

R. Adam Horch, Jeffry S. Nyman, Mark D. Does
Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, United States of America
R. Adam Horch, Daniel F. Gochberg, Mark D. Does
Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States of America
Daniel F. Gochberg, Mark D. Does
Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America
Jeffry S. Nyman
VA Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America
Jeffry S. Nyman
Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
Jeffry S. Nyman
Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
Mark D. Does
Department of Electrical Engineering, Vanderbilt University, Nashville, Tennessee, United States of America

Corresponding Authors

Competing Interests

The authors have filed a provisional patent on inventions related to the findings presented in this manuscript. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RAH DFG JSN MDD. Performed the experiments: RAH. Analyzed the data: RAH. Contributed reagents/materials/analysis tools: RAH DFG JSN MDD. Wrote the paper: JSN MDD. Supervised the project: JSN MDD.