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Research Article

Chronic CSE Treatment Induces the Growth of Normal Oral Keratinocytes via PDK2 Upregulation, Increased Glycolysis and HIF1α Stabilization

  • Wenyue Sun,

    Affiliation: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Steven S. Chang,

    Affiliation: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Yumei Fu,

    Affiliation: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Yan Liu,

    Affiliation: Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Joseph A. Califano mail

    jcalifa@jhmi.edu

    Affiliations: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland, United States of America

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  • Published: January 19, 2011
  • DOI: 10.1371/journal.pone.0016207

About the Authors

Wenyue Sun, Steven S. Chang, Yumei Fu, Joseph A. Califano
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
Yan Liu
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
Joseph A. Califano
Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland, United States of America

Corresponding Author

Email: jcalifa@jhmi.edu

Competing Interests

J.A. Califano is the Director of Research of the Milton J. Dance Head and Neck Endowment. The terms of this arrangement are being managed by the Johns Hopkins University in accordance with its conflict of interest policies. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: WS JC. Performed the experiments: WS SC YF YL. Analyzed the data: WS. Contributed reagents/materials/analysis tools: WS. Wrote the paper: WS JC.