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Research Article

Heterologous Epitope-Scaffold Prime∶Boosting Immuno-Focuses B Cell Responses to the HIV-1 gp41 2F5 Neutralization Determinant

  • Javier Guenaga,

    Affiliation: Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, United States of America

    Current address: IAVI Neutralizing Antibody Center at The Scripps Research Institute (TSRI), La Jolla, California, United States of America

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  • Pia Dosenovic,

    Affiliation: Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

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  • Gilad Ofek,

    Affiliation: Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, United States of America

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  • David Baker,

    Affiliation: University of Washington, Seattle, Washington, United States of America

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  • William R. Schief,

    Affiliation: University of Washington, Seattle, Washington, United States of America

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  • Peter D. Kwong,

    Affiliation: Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Gunilla B. Karlsson Hedestam,

    Affiliation: Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

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  • Richard T. Wyatt mail

    wyatt@scripps.edu

    Affiliation: Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, United States of America

    Current address: IAVI Neutralizing Antibody Center at The Scripps Research Institute (TSRI), La Jolla, California, United States of America

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  • Published: January 26, 2011
  • DOI: 10.1371/journal.pone.0016074

About the Authors

Javier Guenaga, Gilad Ofek, Peter D. Kwong, Richard T. Wyatt
Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, United States of America
Pia Dosenovic, Gunilla B. Karlsson Hedestam
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
David Baker, William R. Schief
University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: wyatt@scripps.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JG RW GKH PD. Performed the experiments: JG PD. Analyzed the data: JG PD. Contributed reagents/materials/analysis tools: JG PD GO PDK WRS DB. Wrote the paper: RW JG GKH PD.