About the Authors

Xiaohui Fan

Contributed equally to this work with: Xiaohui Fan, Li Shao

Affiliation Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

Li Shao

Contributed equally to this work with: Xiaohui Fan, Li Shao

Affiliation Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

Hong Fang

Affiliation Z-Tech Corporation, an ICF International Company at NCTR/FDA, Jefferson, Arizona, United States of America

Weida Tong

chengyy@zju.edu.cn (YC); weida.tong@fda.hhs.gov (WT)

Affiliation National Center for Toxicological Research (NCTR), US Food and Drug Administration, Jefferson, Arizona, United States of America

Yiyu Cheng

chengyy@zju.edu.cn (YC); weida.tong@fda.hhs.gov (WT)

Affiliation Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

Competing Interests

The authors have declared that no competing interests exist. Hong Fang is an employee of Z-Tech Corporation, but there is no competing interest that can bias this work. This affiliation, however, does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: XF HF WT YC. Analyzed the data: XF LS. Wrote the paper: XF LS HF WT YC.