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Research Article

A Self-Propagating Matrix Metalloprotease-9 (MMP-9) Dependent Cycle of Chronic Neutrophilic Inflammation

  • Xin Xu,

    Affiliations: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Gregory Fleming James CF Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Patricia L. Jackson,

    Affiliations: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Gregory Fleming James CF Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Scott Tanner,

    Affiliation: Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Matthew T. Hardison,

    Affiliation: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Mojtaba Abdul Roda,

    Affiliation: Division of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

    X
  • James Edwin Blalock,

    Affiliations: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Gregory Fleming James CF Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Amit Gaggar mail

    agaggar@uab.edu

    Affiliations: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Gregory Fleming James CF Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Pulmonary Service, Birmingham VA Medical Center, Birmingham, Alabama, United States of America

    X
  • Published: January 13, 2011
  • DOI: 10.1371/journal.pone.0015781

About the Authors

Xin Xu, Patricia L. Jackson, Matthew T. Hardison, James Edwin Blalock, Amit Gaggar
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Xin Xu, Patricia L. Jackson, James Edwin Blalock, Amit Gaggar
Gregory Fleming James CF Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Scott Tanner
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Mojtaba Abdul Roda
Division of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
Amit Gaggar
Pulmonary Service, Birmingham VA Medical Center, Birmingham, Alabama, United States of America

Corresponding Author

Email: agaggar@uab.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XX JEB AG. Performed the experiments: XX ST MTH MAR. Analyzed the data: XX PLJ AG. Contributed reagents/materials/analysis tools: PLJ. Wrote the paper: XX AG.