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Research Article

Aβ40 Oligomers Identified as a Potential Biomarker for the Diagnosis of Alzheimer's Disease

  • Carol Man Gao equal contributor,

    equal contributor Contributed equally to this work with: Carol Man Gao, Alice Y. Yam

    Affiliation: Research and Development, Novartis Vaccines and Diagnostics, Emeryville, California, United States of America

    X
  • Alice Y. Yam equal contributor,

    equal contributor Contributed equally to this work with: Carol Man Gao, Alice Y. Yam

    Affiliation: Research and Development, Novartis Vaccines and Diagnostics, Emeryville, California, United States of America

    X
  • Xuemei Wang,

    Affiliation: Research and Development, Novartis Vaccines and Diagnostics, Emeryville, California, United States of America

    X
  • Erika Magdangal,

    Affiliation: Research and Development, Novartis Vaccines and Diagnostics, Emeryville, California, United States of America

    X
  • Cleo Salisbury,

    Affiliation: Research and Development, Novartis Vaccines and Diagnostics, Emeryville, California, United States of America

    X
  • David Peretz,

    Affiliation: Research and Development, Novartis Vaccines and Diagnostics, Emeryville, California, United States of America

    X
  • Ronald N. Zuckermann,

    Affiliation: Research and Development, Novartis Vaccines and Diagnostics, Emeryville, California, United States of America

    Current address: Lawrence Berkeley National Laboratory, Molecular Foundry, Berkeley, California, United States of America

    X
  • Michael D. Connolly,

    Affiliation: Research and Development, Novartis Vaccines and Diagnostics, Emeryville, California, United States of America

    Current address: Lawrence Berkeley National Laboratory, Molecular Foundry, Berkeley, California, United States of America

    X
  • Oskar Hansson,

    Affiliation: Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden

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  • Lennart Minthon,

    Affiliation: Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden

    X
  • Henrik Zetterberg,

    Affiliation: Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden

    X
  • Kaj Blennow,

    Affiliation: Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden

    X
  • Joseph P. Fedynyshyn mail,

    joseph.fedynyshyn@novartis.com

    Affiliation: Research and Development, Novartis Vaccines and Diagnostics, Emeryville, California, United States of America

    X
  • Sophie Allauzen

    Affiliation: Research and Development, Novartis Vaccines and Diagnostics, Emeryville, California, United States of America

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  • Published: December 30, 2010
  • DOI: 10.1371/journal.pone.0015725

About the Authors

Carol Man Gao, Alice Y. Yam, Xuemei Wang, Erika Magdangal, Cleo Salisbury, David Peretz, Ronald N. Zuckermann, Michael D. Connolly, Joseph P. Fedynyshyn, Sophie Allauzen
Research and Development, Novartis Vaccines and Diagnostics, Emeryville, California, United States of America
Henrik Zetterberg, Kaj Blennow
Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden
Oskar Hansson, Lennart Minthon
Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden

Corresponding Author

Email: joseph.fedynyshyn@novartis.com

Competing Interests

Several of the authors are employed by Novartis Vaccines and Diagnostics and thus may have a conflict of interest. In addition, the submitted work is included in a pending patent application on amyloid-beta aggregates as biomarkers for Alzheimer's Disease (patent #61/265,340, submitted by Novartis AG on Nov 30, 2009). This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CMG AYY SA JPF DP. Performed the experiments: CMG EM AYY. Analyzed the data: CMG EM AYY JPF. Contributed reagents/materials/analysis tools: XW CS RNZ MDC OH LM HZ KB. Wrote the paper: AYY.