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Research Article

Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome

  • Ted J. Kaptchuk mail,

    ted_kaptchuk@hms.harvard.edu

    Affiliations: Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, Osher Research Center, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Elizabeth Friedlander,

    Affiliation: Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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  • John M. Kelley,

    Affiliations: Psychology Department, Endicott College, Beverly, Massachusetts, United States of America, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • M. Norma Sanchez,

    Affiliation: Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Efi Kokkotou,

    Affiliation: Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Joyce P. Singer,

    Affiliation: Osher Research Center, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Magda Kowalczykowski,

    Affiliation: Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Franklin G. Miller,

    Affiliation: Department of Bioethics, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Irving Kirsch,

    Affiliation: Department of Psychology, University of Hull, Hull, United Kingdom

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  • Anthony J. Lembo

    Affiliation: Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: December 22, 2010
  • DOI: 10.1371/journal.pone.0015591

About the Authors

Ted J. Kaptchuk, Elizabeth Friedlander, M. Norma Sanchez, Efi Kokkotou, Magda Kowalczykowski, Anthony J. Lembo
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
Ted J. Kaptchuk, Joyce P. Singer
Osher Research Center, Harvard Medical School, Boston, Massachusetts, United States of America
John M. Kelley
Psychology Department, Endicott College, Beverly, Massachusetts, United States of America
John M. Kelley
Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Franklin G. Miller
Department of Bioethics, National Institutes of Health, Bethesda, Maryland, United States of America
Irving Kirsch
Department of Psychology, University of Hull, Hull, United Kingdom

Corresponding Author

Email: ted_kaptchuk@hms.harvard.edu

Competing Interests

AJL has worked as a consultant for Ironwood, GSK, Salix, Alkermes, and Ardelyx. These companies have had no relationship to this study. All other authors report no competing interest or appearance of competing interest.

Author Contributions

Conceived and designed the experiments: TJK JMK EK FGM IK AJL. Performed the experiments: AJL EF JMK MNS JPS MK. Analyzed the data: JMK AJL IK TJK MK JPS. Wrote the paper: TJK AJL JMK FGM IK EK.