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Research Article

Intranasal Immunization with an Archaeal Lipid Mucosal Vaccine Adjuvant and Delivery Formulation Protects against a Respiratory Pathogen Challenge

  • Girishchandra B. Patel mail,

    girish.patel@nrc-cnrc.gc.ca

    Affiliation: Institute for Biological Sciences, National Research Council Canada, Ottawa, Canada

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  • Hongyan Zhou,

    Affiliation: Institute for Biological Sciences, National Research Council Canada, Ottawa, Canada

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  • Amalia Ponce,

    Affiliation: Institute for Biological Sciences, National Research Council Canada, Ottawa, Canada

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  • Greg Harris,

    Affiliation: Institute for Biological Sciences, National Research Council Canada, Ottawa, Canada

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  • Wangxue Chen

    Affiliation: Institute for Biological Sciences, National Research Council Canada, Ottawa, Canada

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  • Published: December 29, 2010
  • DOI: 10.1371/journal.pone.0015574

About the Authors

Girishchandra B. Patel, Hongyan Zhou, Amalia Ponce, Greg Harris, Wangxue Chen
Institute for Biological Sciences, National Research Council Canada, Ottawa, Canada

Corresponding Author

Email: girish.patel@nrc-cnrc.gc.ca

Competing Interests

GBP and WC are co-inventors on patent applications (owned by the Crown/Government of Canada) on the archaeal lipid mucosal vaccine adjuvant and delivery (AMVAD) technology. None of the other authors declare any conflicts. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: GBP WC. Performed the experiments: HZ AP GH. Analyzed the data: GBP HZ AP GH WC. Wrote the paper: GBP WC.