About the Authors

Nathalie Landry

landryn@medicago.com

Affiliation Medicago Inc., Québec, Canada

Brian J. Ward

Affiliation Research Institute of the McGill University Health Center, Montreal General Hospital, Montreal, Canada

Sonia Trépanier

Affiliation Medicago Inc., Québec, Canada

Emanuele Montomoli

Affiliation Molecular Epidemiology Research Division, Department of Physiopathology, Experimental Medicine and Public Health, University of Siena, Siena, Italy

Michèle Dargis

Affiliation Medicago Inc., Québec, Canada

Giulia Lapini

Affiliation Molecular Epidemiology Research Division, Department of Physiopathology, Experimental Medicine and Public Health, University of Siena, Siena, Italy

Louis-P. Vézina

Affiliation Medicago Inc., Québec, Canada

Competing Interests

NL, ST, MD and L-PV are employees of Medicago Inc., which sponsored the preclinical and clinical trials. This does not alter the authors' adherence to all the PLOS one policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: NL ST EM. Performed the experiments: BJW MD GL. Analyzed the data: NL BJW ST EM LPV. Contributed reagents/materials/analysis tools: ST EM MD GL. Wrote the paper: NL BJW LPV ST EM.