Advertisement
Research Article

Preclinical and Clinical Development of Plant-Made Virus-Like Particle Vaccine against Avian H5N1 Influenza

  • Nathalie Landry mail,

    landryn@medicago.com

    Affiliation: Medicago Inc., Québec, Canada

    X
  • Brian J. Ward,

    Affiliation: Research Institute of the McGill University Health Center, Montreal General Hospital, Montreal, Canada

    X
  • Sonia Trépanier,

    Affiliation: Medicago Inc., Québec, Canada

    X
  • Emanuele Montomoli,

    Affiliation: Molecular Epidemiology Research Division, Department of Physiopathology, Experimental Medicine and Public Health, University of Siena, Siena, Italy

    X
  • Michèle Dargis,

    Affiliation: Medicago Inc., Québec, Canada

    X
  • Giulia Lapini,

    Affiliation: Molecular Epidemiology Research Division, Department of Physiopathology, Experimental Medicine and Public Health, University of Siena, Siena, Italy

    X
  • Louis-P. Vézina

    Affiliation: Medicago Inc., Québec, Canada

    X
  • Published: December 22, 2010
  • DOI: 10.1371/journal.pone.0015559

About the Authors

Nathalie Landry, Sonia Trépanier, Michèle Dargis, Louis-P. Vézina
Medicago Inc., Québec, Canada
Brian J. Ward
Research Institute of the McGill University Health Center, Montreal General Hospital, Montreal, Canada
Emanuele Montomoli, Giulia Lapini
Molecular Epidemiology Research Division, Department of Physiopathology, Experimental Medicine and Public Health, University of Siena, Siena, Italy

Corresponding Author

Email: landryn@medicago.com

Competing Interests

NL, ST, MD and L-PV are employees of Medicago Inc., which sponsored the preclinical and clinical trials. This does not alter the authors' adherence to all the PLOS one policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: NL ST EM. Performed the experiments: BJW MD GL. Analyzed the data: NL BJW ST EM LPV. Contributed reagents/materials/analysis tools: ST EM MD GL. Wrote the paper: NL BJW LPV ST EM.