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Research Article

The Neurotoxicity of DOPAL: Behavioral and Stereological Evidence for Its Role in Parkinson Disease Pathogenesis

  • W. Michael Panneton mail,

    pannetwm@slu.edu

    Affiliation: Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America

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  • V. B. Kumar,

    Affiliation: Department of Geriatrics, Saint Louis University School of Medicine, St Louis, Missouri, United States of America

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  • Qi Gan,

    Affiliation: Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America

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  • William J. Burke,

    Affiliation: Department of Neurology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America

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  • James E. Galvin

    Affiliation: Department of Neurology and Department of Psychiatry, Center of Excellence on Brain Aging, New York University Langone Medical Center, New York, New York, United States of America

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  • Published: December 13, 2010
  • DOI: 10.1371/journal.pone.0015251

About the Authors

W. Michael Panneton, Qi Gan
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America
V. B. Kumar
Department of Geriatrics, Saint Louis University School of Medicine, St Louis, Missouri, United States of America
William J. Burke
Department of Neurology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America
James E. Galvin
Department of Neurology and Department of Psychiatry, Center of Excellence on Brain Aging, New York University Langone Medical Center, New York, New York, United States of America

Corresponding Author

Email: pannetwm@slu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WMP WJB. Performed the experiments: WMP QG. Analyzed the data: WMP QG WJB. Contributed reagents/materials/analysis tools: WMP VBK JEG. Wrote the paper: WMP WJB JEG.