Nε−Lysine Acetylation of a Bacterial Transcription Factor Inhibits Its DNA-Binding Activity

Sandy Thao; Chien-Sheng Chen; Heng Zhu; Jorge C. Escalante-Semerena

doi:10.1371/journal.pone.0015123

Loading metrics

Open Access

Peer-reviewed

Research Article

N^ε−Lysine Acetylation of a Bacterial Transcription Factor Inhibits Its DNA-Binding Activity

Sandy Thao,

Affiliation Department of Bacteriology, University of Wisconsin, Madison, Wisconsin, United States of America
⨯
Chien-Sheng Chen,

Affiliations Department of Pharmacology and Molecular Sciences and High-Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Graduate Institute of Systems Biology and Bioinformatics, National Central University, Jhongli, Taiwan
⨯
Heng Zhu,

Affiliation Department of Pharmacology and Molecular Sciences and High-Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Jorge C. Escalante-Semerena

* E-mail: escalante@bact.wisc.edu

Affiliation Department of Bacteriology, University of Wisconsin, Madison, Wisconsin, United States of America
⨯

N^ε−Lysine Acetylation of a Bacterial Transcription Factor Inhibits Its DNA-Binding Activity

Sandy Thao,
Chien-Sheng Chen,
Heng Zhu,
Jorge C. Escalante-Semerena

Published: December 31, 2010
https://doi.org/10.1371/journal.pone.0015123

About the Authors

Sandy Thao

Affiliation Department of Bacteriology, University of Wisconsin, Madison, Wisconsin, United States of America

Chien-Sheng Chen

Affiliations Department of Pharmacology and Molecular Sciences and High-Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Graduate Institute of Systems Biology and Bioinformatics, National Central University, Jhongli, Taiwan

Heng Zhu

Affiliation Department of Pharmacology and Molecular Sciences and High-Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Jorge C. Escalante-Semerena

* E-mail: escalante@bact.wisc.edu

Affiliation Department of Bacteriology, University of Wisconsin, Madison, Wisconsin, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ST C-SC HZ JCE-S. Performed the experiments: ST C-SC. Analyzed the data: ST C-SC HZ JCE-S. Contributed reagents/materials/analysis tools: ST C-SC HZ JCE-S. Wrote the paper: ST JCE-S.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Acetylation
Is the Subject Area "Acetylation" applicable to this article?

Thanks for your feedback.
DNA-binding proteins
Is the Subject Area "DNA-binding proteins" applicable to this article?

Thanks for your feedback.
Proteomes
Is the Subject Area "Proteomes" applicable to this article?

Thanks for your feedback.
Electrophoretic mobility shift assay
Is the Subject Area "Electrophoretic mobility shift assay" applicable to this article?

Thanks for your feedback.
Plasmid construction
Is the Subject Area "Plasmid construction" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Microarrays
Is the Subject Area "Microarrays" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.