About the Authors

Young-Kook Choi

Affiliation Department of Pharmaceutics, University of Florida, Gainesville, Florida, United States of America

Kevin Nash

Current address: Molecular Pharmacology and Physiology, Byrd Alzheimer Institute, College of Medicine, University of South Florida, Tampa, Florida, United States of America

Affiliation Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America

Barry J. Byrne

Affiliation Department of Pediatrics, University of Florida, Gainesville, Florida, United States of America

Nicholas Muzyczka

Affiliation Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America

Sihong Song

shsong@ufl.edu

Affiliation Department of Pharmaceutics, University of Florida, Gainesville, Florida, United States of America

Competing Interests

N.M. is an inventor of patents held by the University of Florida related to recombinant AAV technology. He also owns equity in a gene therapy company (AGTC) that is commercializing AAV for gene therapy applications and serves on their Board of Directors. He receives no monetary compensation from AGTC or any other commercial entity. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: Y-KC KN NM SS. Performed the experiments: Y-KC KN SS. Analyzed the data: Y-KC KN NM SS. Contributed reagents/materials/analysis tools: BB NM SS. Wrote the paper: Y-KC KN BB NM SS.