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Research Article

Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism

  • Sarah Garrido-Urbani,

    Affiliation: Department of Pathology and Immunology, Centre Médical Universitaire, University of Geneva, Geneva, Switzerland

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  • Stephane Jemelin,

    Affiliation: Department of Pathology and Immunology, Centre Médical Universitaire, University of Geneva, Geneva, Switzerland

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  • Christine Deffert,

    Affiliation: Department of Pathology and Immunology, Centre Médical Universitaire, University of Geneva, Geneva, Switzerland

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  • Stéphanie Carnesecchi,

    Affiliations: Department of Pathology and Immunology, Centre Médical Universitaire, University of Geneva, Geneva, Switzerland, Department of Pediatrics, Centre Médical Universitaire, University of Geneva, Geneva, Switzerland

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  • Olivier Basset,

    Affiliation: Department of Pathology and Immunology, Centre Médical Universitaire, University of Geneva, Geneva, Switzerland

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  • Cédric Szyndralewiez,

    Affiliation: GenKyoTex S.A., Geneva, Switzerland

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  • Freddy Heitz,

    Affiliation: GenKyoTex S.A., Geneva, Switzerland

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  • Patrick Page,

    Affiliation: GenKyoTex S.A., Geneva, Switzerland

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  • Xavier Montet,

    Affiliation: Department of Physiology and Metabolism, Centre Médical Universitaire, University of Geneva, Geneva, Switzerland

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  • Liliane Michalik,

    Affiliation: Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland

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  • Jack Arbiser,

    Affiliation: Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Curzio Rüegg,

    Affiliation: Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland

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  • Karl Heinz Krause,

    Affiliation: Department of Pathology and Immunology, Centre Médical Universitaire, University of Geneva, Geneva, Switzerland

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  • Beat Imhof mail

    beat.imhof@unige.ch

    Affiliation: Department of Pathology and Immunology, Centre Médical Universitaire, University of Geneva, Geneva, Switzerland

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  • Published: February 07, 2011
  • DOI: 10.1371/journal.pone.0014665

About the Authors

Sarah Garrido-Urbani, Stephane Jemelin, Christine Deffert, Stéphanie Carnesecchi, Olivier Basset, Karl Heinz Krause, Beat Imhof
Department of Pathology and Immunology, Centre Médical Universitaire, University of Geneva, Geneva, Switzerland
Stéphanie Carnesecchi
Department of Pediatrics, Centre Médical Universitaire, University of Geneva, Geneva, Switzerland
Cédric Szyndralewiez, Freddy Heitz, Patrick Page
GenKyoTex S.A., Geneva, Switzerland
Xavier Montet
Department of Physiology and Metabolism, Centre Médical Universitaire, University of Geneva, Geneva, Switzerland
Liliane Michalik
Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
Jack Arbiser
Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, United States of America
Curzio Rüegg
Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland

Corresponding Author

Email: beat.imhof@unige.ch

Competing Interests

A patent is pending on GKT136901 with PP as inventor and GenKyoTex as owner of the patent. PP, CS and K-HK own shares of GenKyoTex. A patent is pending on fulvene-5, with JLA as inventor and Emory University as owner of the patent. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SGU KHK BI. Performed the experiments: SGU SJ CD SC OB CS FH PP. Analyzed the data: SGU. Contributed reagents/materials/analysis tools: CD SC OB CS FH PP XM LM JA CR KHK. Wrote the paper: SGU KHK BI.