Ablation of Akt2 Induces Autophagy through Cell Cycle Arrest, the Downregulation of p70S6K, and the Deregulation of Mitochondria in MDA-MB231 Cells

Stacey A. Santi; Hoyun Lee

doi:10.1371/journal.pone.0014614

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Peer-reviewed

Research Article

Ablation of Akt2 Induces Autophagy through Cell Cycle Arrest, the Downregulation of p70S6K, and the Deregulation of Mitochondria in MDA-MB231 Cells

Stacey A. Santi,

Affiliations Tumor Biology Group, Regional Cancer Program of the Sudbury Regional Hospital, Sudbury, Ontario, Canada, Department of Biochemistry, Microbiology and Immunology, University of Ottawa Medical School, Ottawa, Ontario, Canada
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Hoyun Lee

* E-mail: hlee@hrsrh.on.ca

Affiliations Tumor Biology Group, Regional Cancer Program of the Sudbury Regional Hospital, Sudbury, Ontario, Canada, Department of Biochemistry, Microbiology and Immunology, University of Ottawa Medical School, Ottawa, Ontario, Canada, Division of Medical Sciences, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
⨯

Ablation of Akt2 Induces Autophagy through Cell Cycle Arrest, the Downregulation of p70S6K, and the Deregulation of Mitochondria in MDA-MB231 Cells

Stacey A. Santi,
Hoyun Lee

Published: January 31, 2011
https://doi.org/10.1371/journal.pone.0014614

About the Authors

Stacey A. Santi

Affiliations Tumor Biology Group, Regional Cancer Program of the Sudbury Regional Hospital, Sudbury, Ontario, Canada, Department of Biochemistry, Microbiology and Immunology, University of Ottawa Medical School, Ottawa, Ontario, Canada

Hoyun Lee

* E-mail: hlee@hrsrh.on.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SAS HL. Performed the experiments: SAS. Analyzed the data: SAS HL. Wrote the paper: SAS HL.

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Small interfering RNA
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Transfection
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Mitochondria
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Cell cycle and cell division
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Cell proliferation
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Cyclins
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Autophagic cell death
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Phosphorylation
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