Advertisement
Research Article

Single-Nucleotide Polymorphisms in LPA Explain Most of the Ancestry-Specific Variation in Lp(a) Levels in African Americans

  • Rahul C. Deo equal contributor mail,

    equal contributor Contributed equally to this work with: Rahul C. Deo, James G. Wilson, Chao Xing

    rdeo@partners.org

    Affiliations: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • James G. Wilson equal contributor,

    equal contributor Contributed equally to this work with: Rahul C. Deo, James G. Wilson, Chao Xing

    Affiliations: Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

    X
  • Chao Xing equal contributor,

    equal contributor Contributed equally to this work with: Rahul C. Deo, James G. Wilson, Chao Xing

    Affiliation: Donald W. Reynolds Cardiovascular Clinical Research Center, The Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

    X
  • Kim Lawson,

    Affiliation: Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

    X
  • W. H. Linda Kao,

    Affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

    X
  • David Reich,

    Affiliations: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

    X
  • Arti Tandon,

    Affiliation: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Ermeg Akylbekova,

    Affiliations: Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America, Jackson State University, Jackson, Mississippi, United States of America

    X
  • Nick Patterson,

    Affiliations: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

    X
  • Thomas H. Mosley Jr,

    Affiliation: Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

    X
  • Eric Boerwinkle,

    Affiliation: Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

    X
  • Herman A. Taylor Jr

    Affiliations: Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America, Jackson State University, Jackson, Mississippi, United States of America, Tougaloo College, Tougaloo, Mississippi, United States of America

    X
  • Published: January 24, 2011
  • DOI: 10.1371/journal.pone.0014581

About the Authors

Rahul C. Deo, David Reich, Arti Tandon, Nick Patterson
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
Rahul C. Deo
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Rahul C. Deo
Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
James G. Wilson
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America
James G. Wilson, Ermeg Akylbekova, Thomas H. Mosley Jr, Herman A. Taylor Jr
Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America
Chao Xing
Donald W. Reynolds Cardiovascular Clinical Research Center, The Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
Kim Lawson, Eric Boerwinkle
Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
W. H. Linda Kao
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
David Reich, Nick Patterson
Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America
Ermeg Akylbekova, Herman A. Taylor Jr
Jackson State University, Jackson, Mississippi, United States of America
Herman A. Taylor Jr
Tougaloo College, Tougaloo, Mississippi, United States of America

Corresponding Author

Email: rdeo@partners.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RCD JGW CX DR NP HATJ. Analyzed the data: RCD JGW CX KL WHLK AT ELA NP EB. Contributed reagents/materials/analysis tools: JGW CX DR THMJ EB HATJ. Wrote the paper: RCD JGW.