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Research Article

Sildenafil Reduces Insulin-Resistance in Human Endothelial Cells

  • Caterina Mammi,

    Affiliation: Centre for Clinical and Basic Research, IRCCS San Raffaele Pisana, Rome, Italy

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  • Donatella Pastore,

    Affiliation: Department of Internal Medicine, University of Tor Vergata, Rome, Italy

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  • Marco F. Lombardo,

    Affiliation: Department of Internal Medicine, University of Tor Vergata, Rome, Italy

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  • Francesca Ferrelli,

    Affiliation: Department of Internal Medicine, University of Tor Vergata, Rome, Italy

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  • Massimiliano Caprio,

    Affiliation: Centre for Clinical and Basic Research, IRCCS San Raffaele Pisana, Rome, Italy

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  • Claudia Consoli,

    Affiliation: San Raffaele Sulmona, L'Aquila, Italy

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  • Manfredi Tesauro,

    Affiliation: San Raffaele Sulmona, L'Aquila, Italy

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  • Lucia Gatta,

    Affiliation: San Raffaele Sulmona, L'Aquila, Italy

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  • Massimo Fini,

    Affiliation: San Raffaele Sulmona, L'Aquila, Italy

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  • Massimo Federici,

    Affiliation: Department of Internal Medicine, University of Tor Vergata, Rome, Italy

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  • Paolo Sbraccia,

    Affiliation: Department of Internal Medicine, University of Tor Vergata, Rome, Italy

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  • Giulia Donadel,

    Affiliation: Department of Internal Medicine, University of Tor Vergata, Rome, Italy

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  • Alfonso Bellia,

    Affiliation: Department of Internal Medicine, University of Tor Vergata, Rome, Italy

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  • Giuseppe M. Rosano,

    Affiliation: San Raffaele Sulmona, L'Aquila, Italy

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  • Andrea Fabbri,

    Affiliations: Department of Internal Medicine, University of Tor Vergata, Rome, Italy, Unit of Endocrinology, Department of Internal Medicine, Ospedale S. Eugenio and CTO A. Alesini, University of Tor Vergata, Rome, Italy

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  • Davide Lauro mail

    d.lauro@med.uniroma2.it

    Affiliation: Department of Internal Medicine, University of Tor Vergata, Rome, Italy

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  • Published: January 28, 2011
  • DOI: 10.1371/journal.pone.0014542

About the Authors

Caterina Mammi, Massimiliano Caprio
Centre for Clinical and Basic Research, IRCCS San Raffaele Pisana, Rome, Italy
Donatella Pastore, Marco F. Lombardo, Francesca Ferrelli, Massimo Federici, Paolo Sbraccia, Giulia Donadel, Alfonso Bellia, Andrea Fabbri, Davide Lauro
Department of Internal Medicine, University of Tor Vergata, Rome, Italy
Claudia Consoli, Manfredi Tesauro, Lucia Gatta, Massimo Fini, Giuseppe M. Rosano
San Raffaele Sulmona, L'Aquila, Italy
Andrea Fabbri
Unit of Endocrinology, Department of Internal Medicine, Ospedale S. Eugenio and CTO A. Alesini, University of Tor Vergata, Rome, Italy

Corresponding Author

Email: d.lauro@med.uniroma2.it

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CM DL. Performed the experiments: CM DP ML FF CC LG DL. Analyzed the data: CM DP ML FF MC M. Fini M. Federici PS GD AB GMR AF DL. Contributed reagents/materials/analysis tools: M. Fini DL. Wrote the paper: CM DP MC CC LG DL. Performed several nitric oxide measurements and cell biology experiments: MT.