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Research Article

The Physiological Link between Metabolic Rate Depression and Tau Phosphorylation in Mammalian Hibernation

  • Jens T. Stieler mail,

    jens.stieler@gmx.de

    Affiliations: Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany, Institute of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany

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  • Torsten Bullmann,

    Affiliation: Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany

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  • Franziska Kohl,

    Affiliation: Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska, United States of America

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  • Øivind Tøien,

    Affiliation: Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska, United States of America

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  • Martina K. Brückner,

    Affiliation: Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany

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  • Wolfgang Härtig,

    Affiliation: Department of Pathophysiology of Neuroglia, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany

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  • Brian M. Barnes,

    Affiliation: Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska, United States of America

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  • Thomas Arendt

    Affiliation: Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany

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  • Published: January 18, 2011
  • DOI: 10.1371/journal.pone.0014530

About the Authors

Jens T. Stieler, Torsten Bullmann, Martina K. Brückner, Thomas Arendt
Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany
Jens T. Stieler
Institute of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany
Franziska Kohl, Øivind Tøien, Brian M. Barnes
Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska, United States of America
Wolfgang Härtig
Department of Pathophysiology of Neuroglia, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany

Corresponding Author

Email: jens.stieler@gmx.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JTS BB TA. Performed the experiments: JTS TB FK ØT MKB WH. Analyzed the data: JTS TB FK ØT. Contributed reagents/materials/analysis tools: TB FK ØT BB TA. Wrote the paper: JTS BB TA.