About the Authors

Brooke H. Miller

Affiliation Department of Neuroscience, The Scripps Research Institute-Scripps Florida, Jupiter, Florida, United States of America

Laura E. Schultz

Affiliation Department of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, Jupiter, Florida, United States of America

Anisha Gulati

Affiliation Department of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, Jupiter, Florida, United States of America

Andrew I. Su

Affiliation Genomic Institute of the Novartis Research Foundation, San Diego, California, United States of America

Mathew T. Pletcher

Mathew.Pletcher@pfizer.com

Current address: Compound Safety Prediction, Pfizer Global Research and Development, Groton, Connecticut, United States of America

Affiliation Department of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, Jupiter, Florida, United States of America

Competing Interests

Although the corresponding author is currently employed by a commercial entity, all of the work described in this paper was conducted prior to employment at Pfizer Global Research and Development. Pfizer provided no funding in support of this work other than covering publication fees. There are no competing interests in relation to this current employment status. Andrew Su is employed by the Genomics Institute of the Novartis Research Foundation, but this does not alter the authors' adherence to the PLOS ONE policy on data sharing. The Genomics Institute of the Novartis Research Foundation provided no direct funding for this work or publication and did not play a role in any decisions regarding this work or publication.

Author Contributions

Conceived and designed the experiments: BHM MTP. Performed the experiments: BHM LES AG MTP. Analyzed the data: BHM MTP. Contributed reagents/materials/analysis tools: AIS. Wrote the paper: BHM MTP.