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Research Article

RAF Kinase Activity Regulates Neuroepithelial Cell Proliferation and Neuronal Progenitor Cell Differentiation during Early Inner Ear Development

  • Marta Magariños mail,

    mmagarinos@iib.uam.es

    Affiliations: Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC-UAM, Madrid, Spain, Departamento de Biología, Universidad Autónoma de Madrid, Madrid, Spain, Unit 761, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain

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  • María R. Aburto,

    Affiliations: Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC-UAM, Madrid, Spain, Unit 761, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain

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  • Hortensia Sánchez-Calderón,

    Affiliations: Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC-UAM, Madrid, Spain, Unit 761, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain

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  • Carmen Muñoz-Agudo,

    Affiliation: Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC-UAM, Madrid, Spain

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  • Ulf R. Rapp,

    Affiliation: Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Munich, Germany

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  • Isabel Varela-Nieto

    Affiliations: Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC-UAM, Madrid, Spain, Unit 761, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain

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  • Published: December 28, 2010
  • DOI: 10.1371/journal.pone.0014435

About the Authors

Marta Magariños, María R. Aburto, Hortensia Sánchez-Calderón, Carmen Muñoz-Agudo, Isabel Varela-Nieto
Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC-UAM, Madrid, Spain
Marta Magariños
Departamento de Biología, Universidad Autónoma de Madrid, Madrid, Spain
Marta Magariños, María R. Aburto, Hortensia Sánchez-Calderón, Isabel Varela-Nieto
Unit 761, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain
Ulf R. Rapp
Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Munich, Germany

Corresponding Author

Email: mmagarinos@iib.uam.es

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MM MRA HSC IVN. Performed the experiments: MM MRA CMA. Analyzed the data: MM MRA HSC IVN. Contributed reagents/materials/analysis tools: URR IVN. Wrote the paper: MM URR IVN.