About the Authors

Tudor J. C. Phillips

a.rice@imperial.ac.uk

Affiliation Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital Campus, London, United Kingdom

Catherine L. Cherry

Affiliations Centre for Virology, Burnet Institute, Melbourne, Australia, Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia, Department of Medicine, Monash University, Melbourne, Australia

Sarah Cox

Affiliation Chelsea and Westminster NHS Foundation Trust, London, United Kingdom

Sarah J. Marshall

Affiliation East Kent Hospitals University Foundation Trust and Pilgrims Hospices, Kent, United Kingdom

Andrew S. C. Rice

Affiliation Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital Campus, London, United Kingdom

Competing Interests

ASCR has received fees and associated expenses for research-related consultancy services contracted via Imperial College Consultants from Pfizer, Eisai, Solvay, Spinifex, Organon, Lectus Astellas, Allergan, GSK, NeuroGsx, Esteve and Daiichi Sankyo. ASCR is a member of the EU funded Innovative Medicines Initiative grant “Europain” in which a number of pharmaceutical companies are also participating: Astra-Zeneca, Esteve, Boehinger-Ingelheim, Pfizer, Eli Lilly, GlaxoSmithKline, Wyeth, UCB and Sanofi Aventis. ASCR has also received a research grant from Pfizer; CLC has had investigator initiated research grants from GlaxoSmithKline, Roche Australia and Zymes LLC; CLC is also on the advisory boards of Gilead Science and BMS Australia Virology, honoraria for both have been donated to charity. CLC undertakes consultancy work and is a principle investigator on two clinical studies for CNS Bio; TJCP, SM and SC have no financial interests that may be relevant to the submitted work. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ASCR. Performed the experiments: TP CC SC SJM ASCR. Analyzed the data: TP ASCR. Wrote the paper: TP CC SC ASCR.