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Research Article

Myocarditis in CD8-Depleted SIV-Infected Rhesus Macaques after Short-Term Dual Therapy with Nucleoside and Nucleotide Reverse Transcriptase Inhibitors

  • Lakshmanan Annamalai,

    Affiliation: Division of Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America

    Current address: Department of Animal Resources, Oregon National Primate Research Center, Beaverton, Oregon, United States of America

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  • Susan V. Westmoreland mail,

    susan_westmoreland@hms.harvard.edu

    Affiliation: Division of Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America

    X
  • Heber G. Domingues,

    Affiliation: Division of Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America

    X
  • Dennis G. Walsh,

    Affiliation: Division of Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America

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  • R. Gilberto Gonzalez,

    Affiliation: Neuroradiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

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  • Shawn P. O'Neil

    Affiliation: Division of Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America

    Current address: Pfizer Inc., Andover, Massachusetts, United States of America

    X
  • Published: December 23, 2010
  • DOI: 10.1371/journal.pone.0014429

About the Authors

Lakshmanan Annamalai, Susan V. Westmoreland, Heber G. Domingues, Dennis G. Walsh, Shawn P. O'Neil
Division of Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America
R. Gilberto Gonzalez
Neuroradiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

Corresponding Author

Email: susan_westmoreland@hms.harvard.edu

Competing Interests

None of the authors on this manuscript has any competing interests. Specifically, no author has any competing interests that would interfere with the full and objective presentation and peer review of this manuscript. At the time that this study was conducted at the New England Primate Research Center, Southborough, MA, Dr. Shawn O'Neil was not employed by Pfizer, but was instead employed and appointed through Harvard Medical School, NERPRC. Dr. O'Neil's current position at Pfizer does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LA. Performed the experiments: LA HD DW. Analyzed the data: LA SW SPO. Contributed reagents/materials/analysis tools: GG SPO. Wrote the paper: LA SW GG SPO.