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Research Article

Niclosamide Prevents the Formation of Large Ubiquitin-Containing Aggregates Caused by Proteasome Inhibition

  • Esther Gies equal contributor,

    equal contributor Contributed equally to this work with: Esther Gies, Inga Wilde

    Affiliations: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada, Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Inga Wilde equal contributor,

    equal contributor Contributed equally to this work with: Esther Gies, Inga Wilde

    Affiliations: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada, Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Jason M. Winget,

    Affiliations: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada, Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Maria Brack,

    Affiliations: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada, Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Barak Rotblat,

    Affiliations: Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada, Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Carolina Arias Novoa,

    Affiliations: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada, Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Aruna D. Balgi,

    Affiliation: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Poul H. Sorensen,

    Affiliations: Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada, Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Michel Roberge,

    Affiliation: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Thibault Mayor mail

    mayor@interchange.ubc.ca

    Affiliations: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada, Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Published: December 23, 2010
  • DOI: 10.1371/journal.pone.0014410

About the Authors

Esther Gies, Inga Wilde, Jason M. Winget, Maria Brack, Carolina Arias Novoa, Aruna D. Balgi, Michel Roberge, Thibault Mayor
Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada
Esther Gies, Inga Wilde, Jason M. Winget, Maria Brack, Carolina Arias Novoa, Thibault Mayor
Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia, Canada
Barak Rotblat, Poul H. Sorensen
Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
Barak Rotblat, Poul H. Sorensen
Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada

Corresponding Author

Email: mayor@interchange.ubc.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EG IW JMW BR MR TM. Performed the experiments: EG IW JMW MB BR CAN ADB. Analyzed the data: EG IW JMW BR TM. Contributed reagents/materials/analysis tools: PHS. Wrote the paper: EG IW MR TM.