Advertisement
Research Article

Grifonin-1: A Small HIV-1 Entry Inhibitor Derived from the Algal Lectin, Griffithsin

  • Ewa D. Micewicz,

    Affiliations: Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America, Department of Radiation Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America

    X
  • Amy L. Cole,

    Affiliation: Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America

    X
  • Chun-Ling Jung,

    Affiliation: Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America

    X
  • Hai Luong,

    Affiliation: Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America

    Current address: Astellas Pharma Inc., Santa Monica, California, United States of America

    X
  • Martin L. Phillips,

    Affiliation: Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, California, United States of America

    X
  • Pratikhya Pratikhya,

    Affiliation: Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America

    X
  • Shantanu Sharma,

    Affiliation: Materials and Process Simulation Center, California Institute of Technology, Pasadena, California, United States of America

    X
  • Alan J. Waring,

    Affiliation: Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America

    X
  • Alexander M. Cole,

    Affiliation: Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America

    X
  • Piotr Ruchala mail

    pruchala@mednet.ucla.edu

    Affiliation: Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America

    X
  • Published: December 16, 2010
  • DOI: 10.1371/journal.pone.0014360

About the Authors

Ewa D. Micewicz, Chun-Ling Jung, Hai Luong, Pratikhya Pratikhya, Alan J. Waring, Piotr Ruchala
Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America
Ewa D. Micewicz
Department of Radiation Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America
Amy L. Cole, Alexander M. Cole
Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America
Martin L. Phillips
Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, California, United States of America
Shantanu Sharma
Materials and Process Simulation Center, California Institute of Technology, Pasadena, California, United States of America

Corresponding Author

Email: pruchala@mednet.ucla.edu

Competing Interests

Grifonins and their use are protected by patent rights (provisional application filed, UC case# 2010-087, PR co-inventor). This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PPR. Performed the experiments: EDM ALC CLJ HL MLP PP SS AJW AMC PPR. Analyzed the data: EDM ALC CLJ HL MLP PP SS AJW AMC PPR. Contributed reagents/materials/analysis tools: AMC PPR. Wrote the paper: EDM PPR.