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Research Article

Presymptomatic Risk Assessment for Chronic Non-Communicable Diseases

  • Badri Padhukasahasram equal contributor mail,

    equal contributor Contributed equally to this work with: Badri Padhukasahasram, Eran Halperin

    bpadhuka@ucdavis.edu

    Affiliation: Navigenics, Foster City, California, United States of America

    Current address: Section on Ecology and Evolution and Genome Center, University of California Davis, Davis, California, United States of America

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  • Eran Halperin equal contributor,

    equal contributor Contributed equally to this work with: Badri Padhukasahasram, Eran Halperin

    Affiliation: Navigenics, Foster City, California, United States of America

    Current address: Blavatnik School of Computer Science, Department of Molecular Microbiology and Biotechnology, Tel-Aviv, University, Tel-Aviv, Israel; International Computer Science Institute, Berkeley, California, United States of America

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  • Jennifer Wessel,

    Affiliation: Navigenics, Foster City, California, United States of America

    Current address: School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

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  • Daryl J. Thomas,

    Affiliation: Navigenics, Foster City, California, United States of America

    Current address: Life Technologies, Foster City, California, United States of America

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  • Elana Silver,

    Affiliation: Navigenics, Foster City, California, United States of America

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  • Heather Trumbower,

    Affiliation: Navigenics, Foster City, California, United States of America

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  • Michele Cargill,

    Affiliation: Navigenics, Foster City, California, United States of America

    Current address: Locus Development, San Francisco, California, United States America

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  • Dietrich A. Stephan

    Affiliations: Navigenics, Foster City, California, United States of America, Institute for Individualized Health, Palo Alto, California, United States of America, The Cancer Genome Institute, Philadelphia, Pennsylvania, United States of America, Children's Hospital Informatics Program, Children's Hospital Boston, Boston, Massachusetts, United States of America

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  • Published: December 31, 2010
  • DOI: 10.1371/journal.pone.0014338

About the Authors

Badri Padhukasahasram, Eran Halperin, Jennifer Wessel, Daryl J. Thomas, Elana Silver, Heather Trumbower, Michele Cargill, Dietrich A. Stephan
Navigenics, Foster City, California, United States of America
Dietrich A. Stephan
Institute for Individualized Health, Palo Alto, California, United States of America
Dietrich A. Stephan
The Cancer Genome Institute, Philadelphia, Pennsylvania, United States of America
Dietrich A. Stephan
Children's Hospital Informatics Program, Children's Hospital Boston, Boston, Massachusetts, United States of America

Corresponding Author

Email: bpadhuka@ucdavis.edu

Competing Interests

All the authors were employed at Navigenics Inc when this study was carried out. No other company mentioned in the author affiliations was involved in the study. This is a primary research article and the data used in this study (WTCCC data) was not generated by the company and is available to all qualified researchers. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BKP EH JW MC DS. Performed the experiments: BKP EH JW DJT. Analyzed the data: BKP EH JW DJT ES HT. Contributed reagents/materials/analysis tools: JW DJT ES HT. Wrote the paper: BKP EH DJT ES HT MC DS.