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Research Article

Identification of a Common Lupus Disease-Associated microRNA Expression Pattern in Three Different Murine Models of Lupus

  • Rujuan Dai mail,

    rdai05@vt.edu (RD); ansrahmd@vt.edu (SAA)

    Affiliation: Center for Molecular Medicine and Infectious Diseases (CMMID), Department of Biomedical Sciences and Pathology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

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  • Yan Zhang,

    Affiliation: Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

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  • Deena Khan,

    Affiliation: Center for Molecular Medicine and Infectious Diseases (CMMID), Department of Biomedical Sciences and Pathology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

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  • Bettina Heid,

    Affiliation: Center for Molecular Medicine and Infectious Diseases (CMMID), Department of Biomedical Sciences and Pathology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

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  • David Caudell,

    Affiliation: Center for Molecular Medicine and Infectious Diseases (CMMID), Department of Biomedical Sciences and Pathology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

    X
  • Oswald Crasta,

    Affiliation: Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

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  • S. Ansar Ahmed mail

    rdai05@vt.edu (RD); ansrahmd@vt.edu (SAA)

    Affiliation: Center for Molecular Medicine and Infectious Diseases (CMMID), Department of Biomedical Sciences and Pathology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

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  • Published: December 10, 2010
  • DOI: 10.1371/journal.pone.0014302

About the Authors

Rujuan Dai, Deena Khan, Bettina Heid, David Caudell, S. Ansar Ahmed
Center for Molecular Medicine and Infectious Diseases (CMMID), Department of Biomedical Sciences and Pathology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America
Yan Zhang, Oswald Crasta
Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

Corresponding Authors

Competing Interests

Dr. Rujuan Dai and Dr. S. Ansar Ahmed have filed a provisional patent application through Virginia Tech Intellectual Properties (VTIP) on the finding of the common lupus disease-related miRNAs in lupus mice. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RD SAA. Performed the experiments: RD DK BH. Analyzed the data: RD YZ DC OC. Contributed reagents/materials/analysis tools: YZ. Wrote the paper: RD SAA.