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Research Article

Developing Pulmonary Vasculopathy in Systemic Sclerosis, Detected with Non-Invasive Cardiopulmonary Exercise Testing

  • Daniel Dumitrescu mail,

    daniel.dumitrescu@dd-it.de

    Affiliations: Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America, Division of Respiratory and Critical Care Medicine and Physiology, Klinik III fuer Innere Medizin, Herzzentrum der Universitaet zu Koeln, Cologne, Germany, Klinik III fuer Innere Medizin, Herzzentrum der Universitaet zu Koeln, Cologne, Germany

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  • Ronald J. Oudiz,

    Affiliations: Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America, Division of Cardiology, Klinik III fuer Innere Medizin, Herzzentrum der Universitaet zu Koeln, Cologne, Germany

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  • George Karpouzas,

    Affiliations: Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America, Division of Rheumatology, Klinik III fuer Innere Medizin, Herzzentrum der Universitaet zu Koeln, Cologne, Germany

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  • Arsen Hovanesyan,

    Affiliations: Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America, Division of Cardiology, Klinik III fuer Innere Medizin, Herzzentrum der Universitaet zu Koeln, Cologne, Germany

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  • Amali Jayasinghe,

    Affiliations: Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America, Division of Respiratory and Critical Care Medicine and Physiology, Klinik III fuer Innere Medizin, Herzzentrum der Universitaet zu Koeln, Cologne, Germany

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  • James E. Hansen,

    Affiliations: Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America, Division of Respiratory and Critical Care Medicine and Physiology, Klinik III fuer Innere Medizin, Herzzentrum der Universitaet zu Koeln, Cologne, Germany

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  • Stephan Rosenkranz,

    Affiliation: Klinik III fuer Innere Medizin, Herzzentrum der Universitaet zu Koeln, Cologne, Germany

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  • Karlman Wasserman

    Affiliations: Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America, Division of Respiratory and Critical Care Medicine and Physiology, Klinik III fuer Innere Medizin, Herzzentrum der Universitaet zu Koeln, Cologne, Germany

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  • Published: December 13, 2010
  • DOI: 10.1371/journal.pone.0014293

About the Authors

Daniel Dumitrescu, Ronald J. Oudiz, George Karpouzas, Arsen Hovanesyan, Amali Jayasinghe, James E. Hansen, Karlman Wasserman
Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America
Daniel Dumitrescu, Amali Jayasinghe, James E. Hansen, Karlman Wasserman
Division of Respiratory and Critical Care Medicine and Physiology, Klinik III fuer Innere Medizin, Herzzentrum der Universitaet zu Koeln, Cologne, Germany
Ronald J. Oudiz, Arsen Hovanesyan
Division of Cardiology, Klinik III fuer Innere Medizin, Herzzentrum der Universitaet zu Koeln, Cologne, Germany
George Karpouzas
Division of Rheumatology, Klinik III fuer Innere Medizin, Herzzentrum der Universitaet zu Koeln, Cologne, Germany
Daniel Dumitrescu, Stephan Rosenkranz
Klinik III fuer Innere Medizin, Herzzentrum der Universitaet zu Koeln, Cologne, Germany

Corresponding Author

Email: daniel.dumitrescu@dd-it.de

Competing Interests

DD received an unrestricted research grant from Actelion Pharmaceuticals, and received occasional speaker fees from Actelion. RO received speaker and consulting fees, as well as research grant support from Actelion. SR received speaker and consulting fees as well as research grant support from Actelion. This does not alter the adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DD RO GK JH SR KW. Performed the experiments: DD RO AH AJ. Analyzed the data: DD RO GK AH AJ JH SR KW. Contributed reagents/materials/analysis tools: DD RO GK AH AJ JH SR KW. Wrote the paper: DD RO SR KW. Critical editorial comments: GK AH AJ JH SR.