Advertisement
Research Article

Phenocopy – A Strategy to Qualify Chemical Compounds during Hit-to-Lead and/or Lead Optimization

  • Patrick Baum equal contributor,

    equal contributor Contributed equally to this work with: Patrick Baum, Ramona Schmid

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

    X
  • Ramona Schmid equal contributor,

    equal contributor Contributed equally to this work with: Patrick Baum, Ramona Schmid

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

    X
  • Carina Ittrich,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

    X
  • Werner Rust,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

    X
  • Katrin Fundel-Clemens,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

    X
  • Susanne Siewert,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

    X
  • Martin Baur,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

    X
  • Lisa Mara,

    Affiliation: Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

    X
  • Lore Gruenbaum,

    Affiliation: Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

    X
  • Armin Heckel,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

    X
  • Roland Eils,

    Affiliation: Institute of Pharmacy and Molecular Biotechnology/BIOQUANT, University of Heidelberg, Heidelberg, Germany

    X
  • Roland E. Kontermann,

    Affiliation: Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany

    X
  • Gerald J. Roth,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

    X
  • Florian Gantner,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

    X
  • Andreas Schnapp,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

    X
  • John E. Park,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

    X
  • Andreas Weith,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

    X
  • Karsten Quast,

    Affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

    X
  • Detlev Mennerich mail

    detlev.mennerich@boehringer-ingelheim.com

    Affiliations: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

    X
  • Published: December 10, 2010
  • DOI: 10.1371/journal.pone.0014272

About the Authors

Patrick Baum, Ramona Schmid, Carina Ittrich, Werner Rust, Katrin Fundel-Clemens, Susanne Siewert, Martin Baur, Armin Heckel, Gerald J. Roth, Florian Gantner, Andreas Schnapp, John E. Park, Andreas Weith, Karsten Quast, Detlev Mennerich
Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
Roland E. Kontermann
Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany
Lisa Mara, Lore Gruenbaum, Detlev Mennerich
Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America
Roland Eils
Institute of Pharmacy and Molecular Biotechnology/BIOQUANT, University of Heidelberg, Heidelberg, Germany

Corresponding Author

Email: detlev.mennerich@boehringer-ingelheim.com

Competing Interests

PB, RS, CI, WR, KFC, SS, AH, GJR, FG, AS, JEP, AW and KQ are employees of Boehringer Ingelheim Pharma GmbH and Co. KG DM, LM and LG are employees of Boehringer Ingelheim Pharmaceuticals Inc. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PB RS CI WR RK FG JEP AW KQ DM. Performed the experiments: PB WR SS MB LM DM. Analyzed the data: PB RS CI KFC LM KQ DM. Contributed reagents/materials/analysis tools: PB RS CI WR KFC LG AH RE GJR AS JEP KQ DM. Wrote the paper: PB RS FG AS DM.