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Research Article

Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus

  • Christopher G. Bell equal contributor mail,

    equal contributor Contributed equally to this work with: Christopher G. Bell, Sarah Finer, Cecilia M. Lindgren

    christopher.bell@ucl.ac.uk

    Affiliation: Medical Genomics, UCL Cancer Institute, University College London, London, United Kingdom

    X
  • Sarah Finer equal contributor,

    equal contributor Contributed equally to this work with: Christopher G. Bell, Sarah Finer, Cecilia M. Lindgren

    Affiliation: Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    X
  • Cecilia M. Lindgren equal contributor,

    equal contributor Contributed equally to this work with: Christopher G. Bell, Sarah Finer, Cecilia M. Lindgren

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

    X
  • Gareth A. Wilson,

    Affiliation: Medical Genomics, UCL Cancer Institute, University College London, London, United Kingdom

    X
  • Vardhman K. Rakyan,

    Affiliation: Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    X
  • Andrew E. Teschendorff,

    Affiliation: Medical Genomics, UCL Cancer Institute, University College London, London, United Kingdom

    X
  • Pelin Akan,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

    X
  • Elia Stupka,

    Affiliations: Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, Comparative Genomics, UCL Cancer Institute, University College London, London, United Kingdom

    X
  • Thomas A. Down,

    Affiliations: Gurdon Institute, University of Cambridge, Cambridge, United Kingdom, Department of Genetics, University of Cambridge, Cambridge, United Kingdom

    X
  • Inga Prokopenko,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

    X
  • Ian M. Morison,

    Affiliation: Pathology Department, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand

    X
  • Jonathan Mill,

    Affiliation: Institute of Psychiatry, King's College London, London, United Kingdom

    X
  • Ruth Pidsley,

    Affiliation: Institute of Psychiatry, King's College London, London, United Kingdom

    X
  • International Type 2 Diabetes 1q Consortium,
  • Panos Deloukas,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

    X
  • Timothy M. Frayling,

    Affiliation: Institute of Biomedical and Clinical Science, Peninsula Medical School, University of Exeter, Exeter, United Kingdom

    X
  • Andrew T. Hattersley,

    Affiliation: Institute of Biomedical and Clinical Science, Peninsula Medical School, University of Exeter, Exeter, United Kingdom

    X
  • Mark I. McCarthy ,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

    These authors also contributed equally to this work.

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  • Stephan Beck ,

    Affiliation: Medical Genomics, UCL Cancer Institute, University College London, London, United Kingdom

    These authors also contributed equally to this work.

    X
  • Graham A. Hitman

    Affiliation: Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    These authors also contributed equally to this work.

    X
  • Published: November 18, 2010
  • DOI: 10.1371/journal.pone.0014040

About the Authors

Christopher G. Bell, Gareth A. Wilson, Andrew E. Teschendorff, Stephan Beck
Medical Genomics, UCL Cancer Institute, University College London, London, United Kingdom
Sarah Finer, Vardhman K. Rakyan, Elia Stupka, Graham A. Hitman
Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Cecilia M. Lindgren, Inga Prokopenko, Mark I. McCarthy
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Pelin Akan, Panos Deloukas
Wellcome Trust Sanger Institute, Hinxton, United Kingdom
Elia Stupka
Comparative Genomics, UCL Cancer Institute, University College London, London, United Kingdom
Thomas A. Down
Gurdon Institute, University of Cambridge, Cambridge, United Kingdom
Thomas A. Down
Department of Genetics, University of Cambridge, Cambridge, United Kingdom
Ian M. Morison
Pathology Department, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
Jonathan Mill, Ruth Pidsley
Institute of Psychiatry, King's College London, London, United Kingdom
Timothy M. Frayling, Andrew T. Hattersley
Institute of Biomedical and Clinical Science, Peninsula Medical School, University of Exeter, Exeter, United Kingdom

Corresponding Author

Email: christopher.bell@ucl.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CGB CML VKR PD MIM SB GAH. Performed the experiments: CGB SF VKR PA. Analyzed the data: CGB GAW AET PA. Contributed reagents/materials/analysis tools: CGB CML GAW AET ES TAD IP IMM JM RP NN TMF ATH. Wrote the paper: CGB SF SB GAH.