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Research Article

Cucurbitacin I Inhibits Cell Motility by Indirectly Interfering with Actin Dynamics

  • David A. Knecht mail,

    david.knecht@uconn.edu (DAK); gabriel.fenteany@uconn.edu (GF)

    Affiliation: Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, United States of America

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  • Rebecca A. LaFleur,

    Affiliation: Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, United States of America

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  • Alem W. Kahsai,

    Affiliation: Department of Chemistry, University of Connecticut, Storrs, Connecticut, United States of America

    Current address: Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Christian E. Argueta,

    Affiliation: Department of Chemistry, University of Connecticut, Storrs, Connecticut, United States of America

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  • Anwar B. Beshir,

    Affiliation: Department of Chemistry, University of Connecticut, Storrs, Connecticut, United States of America

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  • Gabriel Fenteany mail

    david.knecht@uconn.edu (DAK); gabriel.fenteany@uconn.edu (GF)

    Affiliation: Department of Chemistry, University of Connecticut, Storrs, Connecticut, United States of America

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  • Published: November 24, 2010
  • DOI: 10.1371/journal.pone.0014039

About the Authors

David A. Knecht, Rebecca A. LaFleur
Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, United States of America
Alem W. Kahsai, Christian E. Argueta, Anwar B. Beshir, Gabriel Fenteany
Department of Chemistry, University of Connecticut, Storrs, Connecticut, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DAK GF. Performed the experiments: DAK RL AWK CEA ABB. Analyzed the data: DAK RL AWK CEA ABB GF. Wrote the paper: DAK GF.