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Research Article

Rapid Transient Production in Plants by Replicating and Non-Replicating Vectors Yields High Quality Functional Anti-HIV Antibody

  • Frank Sainsbury mail,

    frank.sainsbury.1@ulaval.ca

    Affiliation: Department of Biological Chemistry, John Innes Centre, Norwich, United Kingdom

    Current address: Département de Phytologie, Université Laval, Québec, Canada

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  • Markus Sack,

    Affiliation: Institute for Molecular Biotechnology, Rheinisch-Westfälische Technische Hochschule (RWTH), Aachen, Germany

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  • Johannes Stadlmann,

    Affiliation: Department for Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria

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  • Heribert Quendler,

    Affiliation: Institute of Applied Microbiology, University of Natural Resources and Applied Life Sciences, Vienna, Austria

    Current address: Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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  • Rainer Fischer,

    Affiliations: Institute for Molecular Biotechnology, Rheinisch-Westfälische Technische Hochschule (RWTH), Aachen, Germany, Fraunhofer Institute for Molecular Biology and Applied Ecology, Aachen, Germany

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  • George P. Lomonossoff

    Affiliation: Department of Biological Chemistry, John Innes Centre, Norwich, United Kingdom

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  • Published: November 12, 2010
  • DOI: 10.1371/journal.pone.0013976

About the Authors

Frank Sainsbury, George P. Lomonossoff
Department of Biological Chemistry, John Innes Centre, Norwich, United Kingdom
Markus Sack, Rainer Fischer
Institute for Molecular Biotechnology, Rheinisch-Westfälische Technische Hochschule (RWTH), Aachen, Germany
Johannes Stadlmann
Department for Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria
Heribert Quendler
Institute of Applied Microbiology, University of Natural Resources and Applied Life Sciences, Vienna, Austria
Rainer Fischer
Fraunhofer Institute for Molecular Biology and Applied Ecology, Aachen, Germany

Corresponding Author

Email: frank.sainsbury.1@ulaval.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FS MS RF GL. Performed the experiments: FS MS JS HQ. Analyzed the data: FS MS JS HQ. Contributed reagents/materials/analysis tools: RF GL. Wrote the paper: FS MS GL.