About the Authors
- Karsten Suhre
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* E-mail: karsten.suhre@helmholtz-muenchen.de
Affiliations Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Faculty of Biology, Ludwig-Maximilians-Universität, Planegg-Martinsried, Germany
- Christa Meisinger
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Affiliation Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
- Angela Döring
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Affiliation Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
- Elisabeth Altmaier
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Affiliation Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
- Petra Belcredi
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Affiliation Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
- Christian Gieger
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Affiliation Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
- David Chang
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Affiliation Chenomx, Edmonton, Alberta, Canada
- Michael V. Milburn
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Affiliation Metabolon Inc., Durham, North Carolina, United States of America
- Walter E. Gall
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Affiliation Metabolon Inc., Durham, North Carolina, United States of America
- Klaus M. Weinberger
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Affiliation Biocrates Life Sciences AG, Innsbruck, Austria
- Hans-Werner Mewes
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Affiliations Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Department of Genome-Oriented Bioinformatics, Life and Food Science Center Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany
- Martin Hrabé de Angelis
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Affiliations Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Experimental Genetics, Life and Food Science Center Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany
- H.-Erich Wichmann
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Affiliations Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität and Klinikum Grosshadern, Munich, Germany
- Florian Kronenberg
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Affiliation Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
- Jerzy Adamski
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Affiliations Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Experimental Genetics, Life and Food Science Center Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany
- Thomas Illig
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Affiliation Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Competing Interests
This study was conducted under the direction of the Helmholtz Zentrum Munich - German Research Center for Environmental Health, independently of Biocrates, Chenomx and Metabolon, who provided the metabolomics measurements on a fee-for-service basis. HMGU researchers did not receive any financial advantages (e.g., consultancy fees) from any of these companies. Co-authorship has been offered to the following members of these companies solely for the value of their scientific input in the interpretation of the data, which was provided free of charge: David Chang, Chenomx Inc.; Michael V. Milburn and Walter E. Gall, Metabolon Inc.; Klaus M. Weinberger, Biocrates Life Sciences AG. This participation of authors from industry does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. Moreover, none of the results presented in this work are presently under consideration for IP protection.
Author Contributions
Conceived and designed the experiments: KS HEW TI. Performed the experiments: DC MVM WGPD KMW. Analyzed the data: KS CM AD EA PB FK JA. Contributed reagents/materials/analysis tools: CG HWM MHdA HEW TI. Wrote the paper: KS CM AD FK JA.