About the Authors

Danlin Jia

Affiliation Department of Immunology, University of Toronto, Toronto, Canada

Ramtin Rahbar

Affiliation Department of Immunology, University of Toronto, Toronto, Canada

Renee W. Y. Chan

Affiliations Department of Pathology, University of Hong Kong, Hong Kong, People's Republic of China, Department of Microbiology, University of Hong Kong, Hong Kong, People's Republic of China

Suki M. Y. Lee

Affiliation Department of Microbiology, University of Hong Kong, Hong Kong, People's Republic of China

Michael C. W. Chan

Affiliation Department of Microbiology, University of Hong Kong, Hong Kong, People's Republic of China

Ben Xuhao Wang

Affiliation Department of Immunology, University of Toronto, Toronto, Canada

Darren P. Baker

Affiliation Biogen Idec Inc., Cambridge, Massachusetts, United States of America

Bing Sun

Affiliation Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People's Republic of China

J. S. Malik Peiris

Affiliation Department of Microbiology, University of Hong Kong, Hong Kong, People's Republic of China

John M. Nicholls

Affiliation Department of Pathology, University of Hong Kong, Hong Kong, People's Republic of China

Eleanor N. Fish

en.fish@utoronto.ca

Affiliations Department of Immunology, University of Toronto, Toronto, Canada, Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Canada

Competing Interests

Darren P. Baker is employed by Biogen Idec. Biogen Idec did not provide funds for these studies, nor was Biogen Idec involved in the study design, data analysis or any decisions relating to manuscript preparation or submission. Biogen Idec provided interferon-beta for these studies at no cost. Accordingly, the relationship with Darren P. Baker (and therefore Biogen Idec) in no way affects adherence to all of the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DJ JSMP JMN ENF. Performed the experiments: DJ RR RWYC SML MCC. Analyzed the data: DJ RR RWYC MCC BXW JSMP JMN ENF. Contributed reagents/materials/analysis tools: DPB BS JMN. Wrote the paper: DJ RR ENF. Involved in editing the manuscript and reviewing the different drafts: DPB. Provided input for data interpretation: DPB. Involved in reviewing the manuscript: BS.