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Research Article

Orally Administered P22 Phage Tailspike Protein Reduces Salmonella Colonization in Chickens: Prospects of a Novel Therapy against Bacterial Infections

  • Shakeeba Waseh,

    Affiliation: Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada

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  • Pejman Hanifi-Moghaddam,

    Affiliation: Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada

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  • Russell Coleman,

    Affiliation: Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada

    X
  • Michael Masotti,

    Affiliation: Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada

    X
  • Shannon Ryan,

    Affiliation: Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada

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  • Mary Foss,

    Affiliation: Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada

    X
  • Roger MacKenzie,

    Affiliations: Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada, Department of Environmental Biology, Ontario Agricultural College, University of Guelph, Guelph, Canada

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  • Matthew Henry,

    Affiliation: Department of Discovery Research, Dow AgroSciences, Indianapolis, Indiana, United States of America

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  • Christine M. Szymanski mail,

    jamshid.tanha@nrc-cnrc.gc.ca (JT); cszymans@ualberta.ca (CMS)

    Affiliation: Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada

    Current address: Department of Biological Sciences, University of Alberta, Alberta Ingenuity Centre for Carbohydrate Science, Edmonton, Canada

    X
  • Jamshid Tanha mail

    jamshid.tanha@nrc-cnrc.gc.ca (JT); cszymans@ualberta.ca (CMS)

    Affiliations: Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada, Department of Environmental Biology, Ontario Agricultural College, University of Guelph, Guelph, Canada, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada

    X
  • Published: November 22, 2010
  • DOI: 10.1371/journal.pone.0013904

About the Authors

Shakeeba Waseh, Pejman Hanifi-Moghaddam, Russell Coleman, Michael Masotti, Shannon Ryan, Mary Foss, Roger MacKenzie, Christine M. Szymanski, Jamshid Tanha
Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada
Roger MacKenzie, Jamshid Tanha
Department of Environmental Biology, Ontario Agricultural College, University of Guelph, Guelph, Canada
Matthew Henry
Department of Discovery Research, Dow AgroSciences, Indianapolis, Indiana, United States of America
Jamshid Tanha
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada

Corresponding Authors

Competing Interests

Matthew Henry contributed to the project's experimental design and is one of the inventors on the above mentioned patent. There is no competing or conflict of interest regarding the content of this manuscript. The authors confirm their agreement to PLoS ONE policies on sharing data and materials by making freely available any materials and information described in this publication that are reasonably requested by others for the purpose of academic, non-commercial research.

Author Contributions

Conceived and designed the experiments: RC RM MH CMS JT. Performed the experiments: SW PHM MM SR MF. Analyzed the data: SW PHM JT. Contributed reagents/materials/analysis tools: RC MM SR MF. Wrote the paper: SW PHM JT. Supervision: JT. Responsible for animal study: RC.