About the Authors

Melodie L. Knowlton

Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Laura M. Selfors

Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Carolyn N. Wrobel

Current address: Department of Biological Sciences, DePaul University, Chicago, Illinois, United States of America

Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Ting-Lei Gu

Affiliation Cell Signaling Technology, Inc., Danvers, Massachusetts, United States of America

Bryan A. Ballif

Current address: Department of Biology, University of Vermont Burlington, Vermont, United States of America

Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Steven P. Gygi

Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Roberto Polakiewicz

Affiliation Cell Signaling Technology, Inc., Danvers, Massachusetts, United States of America

Joan S. Brugge

joan_brugge@hms.harvard.edu

Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

Ting-Lei Gu and Roberto Polakiewicz are employees of Cell Signaling Technology, Inc, but we have no other competing interests. This employment does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MLK CNW RP JSB. Performed the experiments: MLK CNW TLG BAB. Analyzed the data: MLK LS TLG BAB JSB. Contributed reagents/materials/analysis tools: SPG RP. Wrote the paper: MLK JSB.