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Research Article

A Molecular Signature of Proteinuria in Glomerulonephritis

  • Heather N. Reich mail,

    hreich@uhnresearch.on.ca

    Affiliations: Division of Nephrology, University Health Network, University of Toronto, Toronto, Ontario, Canada, The Toronto Glomerulonephritis Registry, Toronto, Ontario, Canada

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  • David Tritchler,

    Affiliations: Division of Epidemiology and Statistics, Ontario Cancer Institute, and University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada

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  • Daniel C. Cattran,

    Affiliations: Division of Nephrology, University Health Network, University of Toronto, Toronto, Ontario, Canada, The Toronto Glomerulonephritis Registry, Toronto, Ontario, Canada

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  • Andrew M. Herzenberg †,

    † Deceased.

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  • Felix Eichinger,

    Affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Anissa Boucherot,

    Affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Anna Henger,

    Affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Celine C. Berthier,

    Affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Viji Nair,

    Affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Clemens D. Cohen,

    Affiliation: Division of Nephrology and Institute of Physiology, University Hospital Zurich, Zurich, Switzerland

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  • James W. Scholey equal contributor,

    equal contributor Contributed equally to this work with: James W. Scholey, Matthias Kretzler

    Affiliations: Division of Nephrology, University Health Network, University of Toronto, Toronto, Ontario, Canada, The Toronto Glomerulonephritis Registry, Toronto, Ontario, Canada

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  • Matthias Kretzler equal contributor

    equal contributor Contributed equally to this work with: James W. Scholey, Matthias Kretzler

    Affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Published: October 18, 2010
  • DOI: 10.1371/journal.pone.0013451

About the Authors

Heather N. Reich, Daniel C. Cattran, James W. Scholey
Division of Nephrology, University Health Network, University of Toronto, Toronto, Ontario, Canada
Heather N. Reich, Daniel C. Cattran, James W. Scholey
The Toronto Glomerulonephritis Registry, Toronto, Ontario, Canada
David Tritchler
Division of Epidemiology and Statistics, Ontario Cancer Institute, and University of Toronto, Toronto, Ontario, Canada
David Tritchler
Department of Laboratory Medicine and Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada
Felix Eichinger, Anissa Boucherot, Anna Henger, Celine C. Berthier, Viji Nair, Matthias Kretzler
Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
Clemens D. Cohen
Division of Nephrology and Institute of Physiology, University Hospital Zurich, Zurich, Switzerland

Corresponding Author

Email: hreich@uhnresearch.on.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HNR DT AMH FE AH CB CDC JWS MK. Performed the experiments: HNR AB AH CDC. Analyzed the data: HNR DT DC FE AB AH CB VN JWS MK. Contributed reagents/materials/analysis tools: DC AMH CDC JWS MK. Wrote the paper: HNR JWS MK. Reviewed the manuscript: AMH.