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Research Article

Immunomodulation Targeting Abnormal Protein Conformation Reduces Pathology in a Mouse Model of Alzheimer's Disease

  • Fernando Goñi,

    Affiliations: Department of Neurology, New York University School of Medicine, New York, New York, United States of America, Department of Immunology, School of Chemistry, University of Uruguay, Montevideo, Uruguay

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  • Frances Prelli,

    Affiliation: Department of Neurology, New York University School of Medicine, New York, New York, United States of America

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  • Yong Ji,

    Affiliation: Department of Neurology, New York University School of Medicine, New York, New York, United States of America

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  • Henrieta Scholtzova,

    Affiliation: Department of Neurology, New York University School of Medicine, New York, New York, United States of America

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  • Jing Yang,

    Affiliation: Department of Neurology, New York University School of Medicine, New York, New York, United States of America

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  • Yanjie Sun,

    Affiliation: Department of Neurology, New York University School of Medicine, New York, New York, United States of America

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  • Feng-Xia Liang,

    Affiliation: Image Core Facility, New York University School of Medicine, New York, New York, United States of America

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  • Regina Kascsak,

    Affiliation: New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

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  • Richard Kascsak,

    Affiliation: New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

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  • Pankaj Mehta,

    Affiliation: New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

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  • Thomas Wisniewski mail

    Thomas.wisniewski@nyumc.org

    Affiliations: Department of Neurology, New York University School of Medicine, New York, New York, United States of America, Department of Pathology, New York University School of Medicine, New York, New York, United States of America, Department of Psychiatry, New York University School of Medicine, New York, New York, United States of America

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  • Published: October 13, 2010
  • DOI: 10.1371/journal.pone.0013391

About the Authors

Fernando Goñi, Frances Prelli, Yong Ji, Henrieta Scholtzova, Jing Yang, Yanjie Sun, Thomas Wisniewski
Department of Neurology, New York University School of Medicine, New York, New York, United States of America
Thomas Wisniewski
Department of Pathology, New York University School of Medicine, New York, New York, United States of America
Thomas Wisniewski
Department of Psychiatry, New York University School of Medicine, New York, New York, United States of America
Feng-Xia Liang
Image Core Facility, New York University School of Medicine, New York, New York, United States of America
Regina Kascsak, Richard Kascsak, Pankaj Mehta
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America
Fernando Goñi
Department of Immunology, School of Chemistry, University of Uruguay, Montevideo, Uruguay

Corresponding Author

Email: Thomas.wisniewski@nyumc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FG TW. Performed the experiments: FG FP YJ HS JY YS FXL PM. Analyzed the data: TW. Contributed reagents/materials/analysis tools: RK RK. Wrote the paper: TW.