About the Authors

Miralem Mrkonjic

Affiliations Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada

Nicole M. Roslin

Affiliation Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario, Canada

Celia M. Greenwood

Affiliations Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario, Canada, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

Stavroula Raptis

Affiliations Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada

Aaron Pollett

Affiliation Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada

Peter W. Laird

Affiliation University of Southern California Epigenome Center, University of Southern California, Los Angeles, California, United States of America

Vaijayanti V. Pethe

Affiliation Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

Theodore Chiang

Affiliation Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario, Canada

Darshana Daftary

Affiliation Ontario Familial Colorectal Cancer Registry, Cancer Care Ontario, Toronto, Ontario, Canada

Elizabeth Dicks

Affiliation Clinical Epidemiology Unit, Memorial University of Newfoundland, St. John's, Newfoundland, Canada

Stephen N. Thibodeau

Affiliation Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America

Steven Gallinger

Affiliations Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, Ontario Familial Colorectal Cancer Registry, Cancer Care Ontario, Toronto, Ontario, Canada, Department of Surgery, University of Toronto, Toronto, Ontario, Canada

Patrick S. Parfrey

Affiliation Clinical Epidemiology Unit, Memorial University of Newfoundland, St. John's, Newfoundland, Canada

H. Banfield Younghusband

Affiliation Discipline of Genetics, Memorial University of Newfoundland, St. John's, Newfoundland, Canada

John D. Potter

Affiliation Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, Seattle, Washington, United States of America

Thomas J. Hudson

Affiliations Ontario Institute for Cancer Research, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

John R. McLaughlin

Affiliations Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada, Ontario Familial Colorectal Cancer Registry, Cancer Care Ontario, Toronto, Ontario, Canada

Roger C. Green

Affiliation Discipline of Genetics, Memorial University of Newfoundland, St. John's, Newfoundland, Canada

Brent W. Zanke

Affiliations Ontario Familial Colorectal Cancer Registry, Cancer Care Ontario, Toronto, Ontario, Canada, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

Polly A. Newcomb

Affiliation Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, Seattle, Washington, United States of America

Andrew D. Paterson

Affiliations Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario, Canada, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

Bharati Bapat

bapat@lunenfeld.ca

Affiliations Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MM NMR CMTG AP BB. Performed the experiments: MM SR AFP PWL VP. Analyzed the data: MM NMR CMTG TC. Contributed reagents/materials/analysis tools: CMTG DD ED ST SG PSP HBY JP TJH JRM RCG BZ PAN AP BB. Wrote the paper: MM NMR JP PAN AP BB.