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Research Article

Abnormalities in Oxygen Sensing Define Early and Late Onset Preeclampsia as Distinct Pathologies

  • Alessandro Rolfo,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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  • Ariel Many,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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  • Antonella Racano,

    Affiliations: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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  • Reshef Tal,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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  • Andrea Tagliaferro,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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  • Francesca Ietta,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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  • Jinxia Wang,

    Affiliation: The Hospital for Sick Children, Toronto, Ontario, Canada

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  • Martin Post,

    Affiliations: Department of Physiology, University of Toronto, Toronto, Ontario, Canada, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada, The Hospital for Sick Children, Toronto, Ontario, Canada

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  • Isabella Caniggia mail

    caniggia@lunenfeld.ca

    Affiliations: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada, Department of Physiology, University of Toronto, Toronto, Ontario, Canada, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada

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  • Published: October 12, 2010
  • DOI: 10.1371/journal.pone.0013288

About the Authors

Alessandro Rolfo, Ariel Many, Antonella Racano, Reshef Tal, Andrea Tagliaferro, Francesca Ietta, Isabella Caniggia
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Isabella Caniggia
Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada
Antonella Racano, Martin Post, Isabella Caniggia
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Martin Post, Isabella Caniggia
Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
Jinxia Wang, Martin Post
The Hospital for Sick Children, Toronto, Ontario, Canada

Corresponding Author

Email: caniggia@lunenfeld.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AR AM MP IC. Performed the experiments: AR AM AR RT AT FI JW IC. Analyzed the data: AR IC. Contributed reagents/materials/analysis tools: MP. Wrote the paper: AR MP IC.