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Research Article

In Vivo Islet Protection by a Nuclear Import Inhibitor in a Mouse Model of Type 1 Diabetes

  • Daniel J. Moore,

    Affiliations: Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Pediatrics, Ian Burr Division of Endocrinology and Diabetes, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Jozef Zienkiewicz,

    Affiliation: Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Peggy L. Kendall,

    Affiliation: Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Danya Liu,

    Affiliations: Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Surgery and Emory Transplant Center, Emory University, Atlanta, Georgia, United States of America

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  • Xueyan Liu,

    Affiliation: Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Ruth Ann Veach,

    Affiliation: Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Robert D. Collins,

    Affiliation: Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Jacek Hawiger mail

    jacek.hawiger@vanderbilt.edu

    Affiliation: Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Published: October 06, 2010
  • DOI: 10.1371/journal.pone.0013235

About the Authors

Daniel J. Moore, Jozef Zienkiewicz, Danya Liu, Xueyan Liu, Ruth Ann Veach, Jacek Hawiger
Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
Daniel J. Moore
Department of Pediatrics, Ian Burr Division of Endocrinology and Diabetes, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
Peggy L. Kendall
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
Robert D. Collins
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
Danya Liu
Department of Surgery and Emory Transplant Center, Emory University, Atlanta, Georgia, United States of America

Corresponding Author

Email: jacek.hawiger@vanderbilt.edu

Competing Interests

XL, DL, RAV, RDC, and JH are listed on patents for cSN50. These patents include 6,043,339, 7,576,058, and pending, entitled “Method for Importing Biologically Active Molecules into Cells” and “Cell Permeable Peptides for Inhibition of Inflammatory Reactions and Methods of use”. This does not alter the authors' ability to adhere fully to all the PLoS ONE policies on sharing data and materials, as detailed in the guide for authors.

Author Contributions

Conceived and designed the experiments: DJM JZ PLK RDC JH. Performed the experiments: DJM JZ DL XL RAV. Analyzed the data: DJM PLK DL RAV RDC JH. Wrote the paper: DJM JH.