About the Authors

Sujana Ghanta

Affiliations Division of Cardiothoracic Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Department of Computer Science and Engineering, University of Louisville, Louisville, Kentucky, United States of America

Michael E. Mitchell

Affiliation Division of Cardiothoracic Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

Mary Ames

Affiliation Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

Mats Hidestrand

Affiliation Division of Cardiothoracic Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

Pippa Simpson

Affiliation Division of Quantitative Health Sciences, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

Mary Goetsch

Affiliation Division of Cardiothoracic Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

William G. Thilly

Affiliation Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Craig A. Struble

Affiliation Department of Mathematics, Statistics, and Computer Science, Marquette University, Milwaukee, Wisconsin, United States of America

Aoy Tomita-Mitchell

amitchell@mcw.edu

Affiliation Division of Cardiothoracic Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

Competing Interests

Sujana Ghanta, Mary Ames, Mats Hidestrand, Mary Goetsch, and Craig Struble have been given stock options of Tandem Diagnostics, the company that is developing the technology the authors have reported in this study. Sujana Ghanta, Mary Ames, and Craig Struble currently serve as consultants to Tandem Diagnostics. Michael E. Mitchell is a board member, shareholder, and consultant of Tandem Diagnostics. Aoy Tomita-Mitchell is a shareholder of Tandem Diagnostics. Tandem Diagnostics also currently has a sponsored research with Dr. Aoy Tomita-Mitchell's and Michael E. Mitchell's labs at the Medical College of Wisconsin for research that is further development of this reported technology. Mats Hidestrand and Mary Goetsch work for Dr. Aoy Tomita-Mitchell's lab at the Medical College of Wisconsin and receive part of their salaries for this research. Michael E. Mitchell, William Thilly, and Aoy Tomita-Mitchell are also inventors on patent applications involving the technology reported herein. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SG MEM ATM. Performed the experiments: SG MH MG. Analyzed the data: SG MH MG. Contributed reagents/materials/analysis tools: MA PS ATM. Wrote the paper: SG MEM MH PS CAS ATM. Contributed new methods: ATM SG MEM WGT. Statistical analysis: PS. Performed phased haplotype analysis: CAS.