About the Authors

Pablo D. Becker

Contributed equally to this work with: Pablo D. Becker, Nicolas Legrand

Affiliation Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany

Nicolas Legrand

Contributed equally to this work with: Pablo D. Becker, Nicolas Legrand

Affiliation Department of Cell Biology and Histology, Academic Medical Center of the University of Amsterdam (AMC-UvA), Center for Immunology Amsterdam (CIA), Amsterdam, The Netherlands

Caroline M. M. van Geelen

Affiliation AIMM Therapeutics, Amsterdam, The Netherlands

Miriam Noerder

Affiliation Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany

Nicholas D. Huntington

Affiliations Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris, France, INSERM U668, Institut Pasteur, Paris, France

Annick Lim

Affiliation INSERM U668, Institut Pasteur, Paris, France

Etsuko Yasuda

Current address: Department of Medicine, University of Vermont, Burlington, Vermont, United States of America

Affiliation AIMM Therapeutics, Amsterdam, The Netherlands

Sean A. Diehl

Current address: Department of Medicine, University of Vermont, Burlington, Vermont, United States of America

Affiliation Department of Cell Biology and Histology, Academic Medical Center of the University of Amsterdam (AMC-UvA), Center for Immunology Amsterdam (CIA), Amsterdam, The Netherlands

Ferenc A. Scheeren

Current address: Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Palo Alto, California, United States of America

Affiliation Department of Cell Biology and Histology, Academic Medical Center of the University of Amsterdam (AMC-UvA), Center for Immunology Amsterdam (CIA), Amsterdam, The Netherlands

Michael Ott

Affiliation Clinic for Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Twincore Centre of Experimental and Clinical Infection Research, Hannover, Germany

Kees Weijer

Affiliation Department of Cell Biology and Histology, Academic Medical Center of the University of Amsterdam (AMC-UvA), Center for Immunology Amsterdam (CIA), Amsterdam, The Netherlands

Heiner Wedemeyer

Affiliation Clinic for Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Twincore Centre of Experimental and Clinical Infection Research, Hannover, Germany

James P. Di Santo

Affiliations Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris, France, INSERM U668, Institut Pasteur, Paris, France

Tim Beaumont

Affiliation AIMM Therapeutics, Amsterdam, The Netherlands

Carlos A. Guzman

Affiliation Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany

Hergen Spits

Hergen.Spits@amc.uva.nl

Affiliations Department of Cell Biology and Histology, Academic Medical Center of the University of Amsterdam (AMC-UvA), Center for Immunology Amsterdam (CIA), Amsterdam, The Netherlands, AIMM Therapeutics, Amsterdam, The Netherlands

Competing Interests

F.A.S., S.A.D., T.B. and H.S. are listed on a patent application describing the BCL6/BCL-XL technology developed by AIMM Therapeutics. C.M.M.v.G., E.Y., T.B. and H.S. are employees of AIMM Therapeutic. The employees of AIMM Therapeutics all have equity interest. H.S. has personal financial interests in AIMM Therapeutics. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. The other authors have no conflicting financial interests.

Author Contributions

Conceived and designed the experiments: PDB NL CMMvG. Performed the experiments: PDB NL CMMvG MN NH AL EY SAD FAS. Analyzed the data: PDB NL CMMvG NH AL MO HW JPDS TB CAG HS. Contributed reagents/materials/analysis tools: KW. Wrote the paper: PDB NL CMMvG NH JPDS TB CAG HS.