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Research Article

β2-Syntrophin Is a Cdk5 Substrate That Restrains the Motility of Insulin Secretory Granules

  • Sandra Schubert,

    Affiliations: Molecular Diabetology, Paul Langerhans Institute Dresden, Uniklinikum Carl Gustav Carus at Dresden University of Technology, Dresden, Germany, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

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  • Klaus-Peter Knoch,

    Affiliation: Molecular Diabetology, Paul Langerhans Institute Dresden, Uniklinikum Carl Gustav Carus at Dresden University of Technology, Dresden, Germany

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  • Joke Ouwendijk,

    Affiliation: Molecular Diabetology, Paul Langerhans Institute Dresden, Uniklinikum Carl Gustav Carus at Dresden University of Technology, Dresden, Germany

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  • Shabaz Mohammed,

    Affiliation: Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark

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  • Yury Bodrov,

    Affiliation: Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

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  • Melanie Jäger,

    Affiliation: Molecular Diabetology, Paul Langerhans Institute Dresden, Uniklinikum Carl Gustav Carus at Dresden University of Technology, Dresden, Germany

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  • Anke Altkrüger,

    Affiliation: Molecular Diabetology, Paul Langerhans Institute Dresden, Uniklinikum Carl Gustav Carus at Dresden University of Technology, Dresden, Germany

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  • Carolin Wegbrod,

    Affiliations: Molecular Diabetology, Paul Langerhans Institute Dresden, Uniklinikum Carl Gustav Carus at Dresden University of Technology, Dresden, Germany, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

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  • Marvin E. Adams,

    Affiliation: Department of Physiology and Biophysics, University of Washington, Seattle, Washington, United States of America

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  • Yong Kim,

    Affiliation: Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York, United States of America

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  • Stanley C. Froehner,

    Affiliation: Department of Physiology and Biophysics, University of Washington, Seattle, Washington, United States of America

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  • Ole N. Jensen,

    Affiliation: Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark

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  • Yannis Kalaidzidis,

    Affiliations: Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany, A. N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia

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  • Michele Solimena mail

    michele.solimena@tu-dresden.de

    Affiliations: Molecular Diabetology, Paul Langerhans Institute Dresden, Uniklinikum Carl Gustav Carus at Dresden University of Technology, Dresden, Germany, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

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  • Published: September 23, 2010
  • DOI: 10.1371/journal.pone.0012929

About the Authors

Sandra Schubert, Klaus-Peter Knoch, Joke Ouwendijk, Melanie Jäger, Anke Altkrüger, Carolin Wegbrod, Michele Solimena
Molecular Diabetology, Paul Langerhans Institute Dresden, Uniklinikum Carl Gustav Carus at Dresden University of Technology, Dresden, Germany
Sandra Schubert, Yury Bodrov, Carolin Wegbrod, Yannis Kalaidzidis, Michele Solimena
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Shabaz Mohammed, Ole N. Jensen
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
Marvin E. Adams, Stanley C. Froehner
Department of Physiology and Biophysics, University of Washington, Seattle, Washington, United States of America
Yong Kim
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York, United States of America
Yannis Kalaidzidis
A. N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia

Corresponding Author

Email: michele.solimena@tu-dresden.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SS. Performed the experiments: SS KPK JO SM MJ AA CW. Analyzed the data: SS JO SM YB YK. Contributed reagents/materials/analysis tools: MEA YK SCF ONJ. Wrote the paper: SS MS. Supervisor: MS.