About the Authors

Thomas E. Edwards

tedwards@embios.com

Affiliations Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, United States of America, Emerald BioStructures, Bainbridge Island, Washington, United States of America

Isabelle Phan

Affiliations Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, United States of America, Seattle Biomedical Research Institute, Seattle, Washington, United States of America

Jan Abendroth

Affiliations Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, United States of America, Emerald BioStructures, Bainbridge Island, Washington, United States of America

Shellie H. Dieterich

Affiliations Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, United States of America, Emerald BioStructures, Bainbridge Island, Washington, United States of America

Amir Masoudi

Affiliations Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, United States of America, Seattle Biomedical Research Institute, Seattle, Washington, United States of America

Wenjin Guo

Affiliations Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, United States of America, Seattle Biomedical Research Institute, Seattle, Washington, United States of America

Stephen N. Hewitt

Affiliations Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, United States of America, School of Medicine, University of Washington, Seattle, Washington, United States of America

Angela Kelley

Affiliations Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, United States of America, School of Medicine, University of Washington, Seattle, Washington, United States of America

David Leibly

Affiliations Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, United States of America, School of Medicine, University of Washington, Seattle, Washington, United States of America

Mitch J. Brittnacher

Affiliation Departments of Microbiology, Medicine, Genome Sciences, and Immunology, University of Washington, Seattle, Washington, United States of America

Bart L. Staker

Affiliations Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, United States of America, Emerald BioStructures, Bainbridge Island, Washington, United States of America

Samuel I. Miller

Affiliation Departments of Microbiology, Medicine, Genome Sciences, and Immunology, University of Washington, Seattle, Washington, United States of America

Wesley C. Van Voorhis

Affiliations Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, United States of America, School of Medicine, University of Washington, Seattle, Washington, United States of America

Peter J. Myler

Affiliations Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, United States of America, Seattle Biomedical Research Institute, Seattle, Washington, United States of America

Lance J. Stewart

Affiliations Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, United States of America, Emerald BioStructures, Bainbridge Island, Washington, United States of America

Competing Interests

Several authors of the mansucript (TEE, JA, SHD, BLS, LJS) work for Emerald BioStructures Inc., a commercial company, and are therefore required to declare their affilitation to this company. Emerald is a subcontractor through the Seattle Biomedical Research Institute (SBRI), and PJM is PI on the Seattle Structural Genomics Center for Infectious Disease (SSGCID), which is funded by the National Institute for Allergy and Infectious Disease (NIAID). This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. All materials and data have been made publically available through the appropriate public repositories (e.g. PDB, BEI, targetDB, etc). In addition, these materials may be obtained directly from the authors.

Author Contributions

Conceived and designed the experiments: TEE IP JA BLS SIM WCVV PJM LJS. Performed the experiments: TEE IP JA SHD AM WG SNH AK DL MJB. Analyzed the data: TEE IP JA. Wrote the paper: TEE IP JA BLS.