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Research Article

Molecular Decoy to the Y-Box Binding Protein-1 Suppresses the Growth of Breast and Prostate Cancer Cells whilst Sparing Normal Cell Viability

  • Jennifer H. Law,

    Affiliation: Laboratory for Oncogenomic Research, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada

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  • Yvonne Li,

    Affiliation: Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada

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  • Karen To,

    Affiliation: Laboratory for Oncogenomic Research, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada

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  • Michelle Wang,

    Affiliation: Laboratory for Oncogenomic Research, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada

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  • Arezoo Astanehe,

    Affiliation: Laboratory for Oncogenomic Research, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada

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  • Karen Lambie,

    Affiliation: Terry Fox Laboratories, BC Cancer Agency, University of British Columbia, Vancouver, British Columbia, Canada

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  • Jaspreet Dhillon,

    Affiliation: Laboratory for Oncogenomic Research, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada

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  • Steven J. M. Jones,

    Affiliation: Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada

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  • Martin E. Gleave,

    Affiliation: The Prostate Centre, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada

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  • Connie J. Eaves,

    Affiliation: Terry Fox Laboratories, BC Cancer Agency, University of British Columbia, Vancouver, British Columbia, Canada

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  • Sandra E. Dunn mail

    sedunn@interchange.ubc.ca

    Affiliation: Laboratory for Oncogenomic Research, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada

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  • Published: September 10, 2010
  • DOI: 10.1371/journal.pone.0012661

About the Authors

Jennifer H. Law, Karen To, Michelle Wang, Arezoo Astanehe, Jaspreet Dhillon, Sandra E. Dunn
Laboratory for Oncogenomic Research, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
Yvonne Li, Steven J. M. Jones
Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada
Martin E. Gleave
The Prostate Centre, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Karen Lambie, Connie J. Eaves
Terry Fox Laboratories, BC Cancer Agency, University of British Columbia, Vancouver, British Columbia, Canada

Corresponding Author

Email: sedunn@interchange.ubc.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JL SED. Performed the experiments: JL YL KT MW AA KL JD. Analyzed the data: JL YL KT. Contributed reagents/materials/analysis tools: JD SMJ MEG CJE. Wrote the paper: JL YL SED.