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Research Article

Estimating the Impact of Plasma HIV-1 RNA Reductions on Heterosexual HIV-1 Transmission Risk

  • Jairam R. Lingappa mail,

    lingappa@uw.edu

    Affiliations: Department of Global Health, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Pediatrics, University of Washington, Seattle, Washington, United States of America

    X
  • James P. Hughes,

    Affiliation: Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

    X
  • Richard S. Wang,

    Affiliation: Department of Global Health, University of Washington, Seattle, Washington, United States of America

    X
  • Jared M. Baeten,

    Affiliations: Department of Global Health, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

    X
  • Connie Celum,

    Affiliations: Department of Global Health, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

    X
  • Glenda E. Gray,

    Affiliation: Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, Republic of South Africa

    X
  • Wendy S. Stevens,

    Affiliations: Department of Molecular Medicine and Haematology, University of the Witwatersrand, Johannesburg, Republic of South Africa, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, Republic of South Africa

    X
  • Deborah Donnell,

    Affiliations: Statistical Center for HIV/AIDS, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Mary S. Campbell,

    Affiliations: Department of Global Health, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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  • Carey Farquhar,

    Affiliations: Department of Global Health, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

    X
  • M. Essex,

    Affiliation: Department of Immunology and Infectious Diseases, School of Public Health, Harvard University, Boston, Massachusetts, United States of America

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  • James I. Mullins,

    Affiliations: Department of Global Health, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Microbiology, University of Washington, Seattle, Washington, United States of America, Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Robert W. Coombs,

    Affiliations: Department of Global Health, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Helen Rees,

    Affiliation: Reproductive Health and HIV Research Unit, University of the Witwatersrand, Johannesburg, Republic of South Africa

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  • Lawrence Corey,

    Affiliations: Department of Global Health, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Anna Wald,

    Affiliations: Department of Global Health, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • for the Partners in Prevention HSV/HIV Transmission Study Team
  • Published: September 13, 2010
  • DOI: 10.1371/journal.pone.0012598

About the Authors

Jairam R. Lingappa, Richard S. Wang, Jared M. Baeten, Connie Celum, Mary S. Campbell, Carey Farquhar, James I. Mullins, Robert W. Coombs, Lawrence Corey, Anna Wald
Department of Global Health, University of Washington, Seattle, Washington, United States of America
Jairam R. Lingappa, Jared M. Baeten, Connie Celum, Mary S. Campbell, Carey Farquhar, James I. Mullins, Robert W. Coombs, Lawrence Corey, Anna Wald
Department of Medicine, University of Washington, Seattle, Washington, United States of America
Jairam R. Lingappa
Department of Pediatrics, University of Washington, Seattle, Washington, United States of America
James P. Hughes
Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
Jared M. Baeten, Connie Celum, Carey Farquhar, Anna Wald
Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
Glenda E. Gray
Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, Republic of South Africa
Wendy S. Stevens
Department of Molecular Medicine and Haematology, University of the Witwatersrand, Johannesburg, Republic of South Africa
Wendy S. Stevens
National Health Laboratory Service, University of the Witwatersrand, Johannesburg, Republic of South Africa
Deborah Donnell
Statistical Center for HIV/AIDS, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Deborah Donnell, Lawrence Corey, Anna Wald
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
M. Essex
Department of Immunology and Infectious Diseases, School of Public Health, Harvard University, Boston, Massachusetts, United States of America
James I. Mullins
Department of Microbiology, University of Washington, Seattle, Washington, United States of America
James I. Mullins, Robert W. Coombs, Lawrence Corey, Anna Wald
Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America
Helen Rees
Reproductive Health and HIV Research Unit, University of the Witwatersrand, Johannesburg, Republic of South Africa

Corresponding Author

Email: lingappa@uw.edu

Competing Interests

CC has received research grant support from GlaxoSmithKline (GSK), which did not include salary support, and has served on an advisory board for GSK. AW has received grant support from Astellas, GSK, and Antigenics; she has been a consultant for Astellas and AiCuris. LC is a consultant for AiCuris and GenPhar. He is the head of the Scientific Advisory Board of Immune Design and receives financial remuneration for this, including equity shares that are <1% ownership.

Author Contributions

Conceived and designed the experiments: JRL JPH JMB CC LC AW. Performed the experiments: JRL JPH RSW JMB CC GEG WSS MSC CF ME HR LC AW. Analyzed the data: JRL JPH RSW JMB CC AW. Contributed reagents/materials/analysis tools: JRL JPH JMB CC MSC JIM RWC AW. Wrote the paper: JRL JPH JMB CC GEG WSS DD MSC CF ME JIM RWC HR LC AW.