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Research Article

DNA Clasping by Mycobacterial HU: The C-Terminal Region of HupB Mediates Increased Specificity of DNA Binding

  • Sandeep Kumar,

    Affiliation: Laboratory of Molecular and Cellular Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India

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  • Abhijit A. Sardesai,

    Affiliation: Laboratory of Bacterial Genetics, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India

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  • Debashree Basu,

    Affiliation: Laboratory of Structural Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India

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  • Kalappagowda Muniyappa,

    Affiliation: Department of Biochemistry, Indian Institute of Science, Bangalore, India

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  • Seyed E. Hasnain mail

    seh@uohyd.ernet.in

    Affiliations: Institute of Life Sciences, University of Hyderabad Campus, Hyderabad, India, Department of Biochemistry, University of Hyderabad, Hyderabad, India, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India

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  • Published: September 02, 2010
  • DOI: 10.1371/journal.pone.0012551

About the Authors

Sandeep Kumar
Laboratory of Molecular and Cellular Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
Abhijit A. Sardesai
Laboratory of Bacterial Genetics, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
Debashree Basu
Laboratory of Structural Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
Kalappagowda Muniyappa
Department of Biochemistry, Indian Institute of Science, Bangalore, India
Seyed E. Hasnain
Institute of Life Sciences, University of Hyderabad Campus, Hyderabad, India
Seyed E. Hasnain
Department of Biochemistry, University of Hyderabad, Hyderabad, India
Seyed E. Hasnain
Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India

Corresponding Author

Email: seh@uohyd.ernet.in

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SK AAS DB. Performed the experiments: SK DB. Analyzed the data: SK AAS DB SEH. Contributed reagents/materials/analysis tools: SEH. Wrote the paper: SK AAS DB KM SEH.