About the Authors

Giuseppe Astarita

Affiliations Department of Pharmacology, University of California Irvine, Irvine, California, United States of America, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy

Kwang-Mook Jung

Affiliation Department of Pharmacology, University of California Irvine, Irvine, California, United States of America

Nicole C. Berchtold

Affiliation Institute for Brain Aging and Dementia, University of California Irvine, Irvine, California, United States of America

Vinh Q. Nguyen

Affiliation Department of Statistics, University of California Irvine, Irvine, California, United States of America

Daniel L. Gillen

Affiliation Department of Statistics, University of California Irvine, Irvine, California, United States of America

Elizabeth Head

Affiliation Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America

Carl W. Cotman

Affiliation Institute for Brain Aging and Dementia, University of California Irvine, Irvine, California, United States of America

Daniele Piomelli

piomelli@uci.edu

Affiliations Department of Pharmacology, University of California Irvine, Irvine, California, United States of America, Department of Biological Chemistry, University of California Irvine, Irvine, California, United States of America, Unit of Drug Discovery and Development, Italian Institute of Technology, Genoa, Italy

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GA DP. Performed the experiments: GA. Analyzed the data: GA KMJ NCB VN DG EH DP. Contributed reagents/materials/analysis tools: GA KMJ NCB VN DG EH CC. Wrote the paper: DP.