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Research Article

Telomerase Inhibition Targets Clonogenic Multiple Myeloma Cells through Telomere Length-Dependent and Independent Mechanisms

  • Sarah K. Brennan,

    Affiliation: Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Qiuju Wang,

    Affiliation: Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Robert Tressler,

    Affiliation: Geron Corporation, Menlo Park, California, United States of America

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  • Calvin Harley,

    Affiliation: Geron Corporation, Menlo Park, California, United States of America

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  • Ning Go,

    Affiliation: Geron Corporation, Menlo Park, California, United States of America

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  • Ekaterina Bassett,

    Affiliation: Geron Corporation, Menlo Park, California, United States of America

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  • Carol Ann Huff,

    Affiliation: Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Richard J. Jones,

    Affiliation: Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • William Matsui mail

    matsuwi@jhmi.edu

    Affiliation: Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Published: September 01, 2010
  • DOI: 10.1371/journal.pone.0012487

About the Authors

Sarah K. Brennan, Qiuju Wang, Carol Ann Huff, Richard J. Jones, William Matsui
Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Robert Tressler, Calvin Harley, Ning Go, Ekaterina Bassett
Geron Corporation, Menlo Park, California, United States of America

Corresponding Author

Email: matsuwi@jhmi.edu

Competing Interests

R.T., C.H., N.G., and E.B. are employees of Geron. W.M. received research funding from Geron. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SKB CH CAH RJJ WM. Performed the experiments: SKB QW NG EB. Analyzed the data: SKB RT NG EB. Contributed reagents/materials/analysis tools: RT CH. Wrote the paper: SKB WM.