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Research Article

Transcriptional Regulation of Human and Rat Hepatic Lipid Metabolism by the Grapefruit Flavonoid Naringenin: Role of PPARα, PPARγ and LXRα

  • Jonathan Goldwasser,

    Affiliations: Center for Engineering in Medicine, Shriners Burns Hospital, Boston, Massachusetts, United States of America, Harvard-MIT Division of Health Science and Technology, Cambridge, Massachusetts, United States of America

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  • Pazit Y. Cohen,

    Affiliation: The Selim and Rachel Benin School of Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel

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  • Eric Yang,

    Affiliations: Center for Engineering in Medicine, Shriners Burns Hospital, Boston, Massachusetts, United States of America, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Patrick Balaguer,

    Affiliation: INSERM, Univ Montpellier I, Montpellier, France

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  • Martin L. Yarmush,

    Affiliations: Center for Engineering in Medicine, Shriners Burns Hospital, Boston, Massachusetts, United States of America, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Yaakov Nahmias mail

    ynahmias@cs.huji.ac.il

    Affiliations: Center for Engineering in Medicine, Shriners Burns Hospital, Boston, Massachusetts, United States of America, The Selim and Rachel Benin School of Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: August 25, 2010
  • DOI: 10.1371/journal.pone.0012399

About the Authors

Jonathan Goldwasser, Eric Yang, Martin L. Yarmush, Yaakov Nahmias
Center for Engineering in Medicine, Shriners Burns Hospital, Boston, Massachusetts, United States of America
Jonathan Goldwasser
Harvard-MIT Division of Health Science and Technology, Cambridge, Massachusetts, United States of America
Pazit Y. Cohen, Yaakov Nahmias
The Selim and Rachel Benin School of Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
Eric Yang, Martin L. Yarmush, Yaakov Nahmias
Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Patrick Balaguer
INSERM, Univ Montpellier I, Montpellier, France

Corresponding Author

Email: ynahmias@cs.huji.ac.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JG YN. Performed the experiments: JG PYC EY PB YN. Analyzed the data: JG PYC YN. Contributed reagents/materials/analysis tools: PB MLY YN. Wrote the paper: JG YN.